ResourceDrug Discovery & Development
Raman spectroscopy as a PAT tool for freeze/thaw applications in the biopharmaceutical industry
1 Sept 2025Biopharmaceuticals like monoclonal antibodies and vaccines require large-scale production and often off-site fill/finish steps, necessitating freezing and long-distance transport. However, freezing can impact product quality due to protein-ice interactions and freeze concentration effects.
Discover how Raman spectroscopy enables real-time, in situ monitoring of formulation components during freeze/thaw processes. Unlike conventional PAT tools that only track temperature, Raman combined with multivariate models provides localized, multi-analyte concentration data, offering a powerful solution to maintain product integrity throughout cold chain operations.
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Raman SpectroscopyRaman spectroscopy is used to discern the vibrational and rotational states of molecules and hence the chemical composition of a sample by measuring the inelastic scattering of monochromatic light. Explore a range of Raman spectrometers, including handheld/portable Raman spectrometers for QC/QA labs and in situ spectrometers for processes. Conduct Raman imaging for microanalysis of mixed samples using a Raman microscope. Raman spectrographs are also available. Find the best Raman spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.proteinDrug Packaging