ResourceSpectroscopy

Quantitative Analysis of APIs in Blending Mixtures and Tablets

12 Aug 2014

This application note demonstrates that Raman spectroscopy with chemometrics can be used to develop a quantitative method to measure the concentration of APIs such as Naltrexone HCl in blending mixtures and final product tablets. The method provides quick predictions of API concentrations in blending mixtures, allowing for use in the on-line monitoring for blending processes. The high sensitivity, high resolution, and stability of the i-Raman Plus instrument conform to the requirements in developing reliable quantitative Raman analysis methods.

i-Raman Plus ‒ Highly Sensitive, High Resolution Fiber Optic Raman System

Metrohm AG

The i-Raman® Plus is an enhanced version of our award winning i-Raman portable Raman spectrometer, now powered by our innovative smart spectrometer technologyUsing a high efficiency back-thinned CCD detector with deeper cooling and high dynamic range, this portable Raman spectrometer delivers an improved signal to noise ratio for up to 30 minutes of integration time, making it possible to measure weak Raman signals.The i-Raman Plus features the unique combination of wide spectral coverage and high resolution with configurations measuring out to 4000cm-1, enabling you to measure stretching bands around 3100cm-1. The system’s small footprint, lightweight design, and low power consumption provide research grade Raman capabilities anywhere. The i-Raman Plus comes standard with a fiber optic probe, probe holder with XYZ positioning stage, cuvette adaptor for measuring liquid samples, and our proprietary BWIQ multi-variant analysis software.With the i-Raman Plus, a high precision qualitative and quantitative Raman solution is at your fingertips.i-Raman Plus ‒ Highly Sensitive, High Resolution Fiber Optic Raman System Features: Smart on-board processing including averaging, smoothing, and dark compensation Our comprehensive package of sampling accessories for measuring solid and liquid samples provide you the utmost utility right out of the box Our state of the art BWIQ quantitative Raman analysis software package provides an intuitive user interface, intelligent algorithms, and efficient matrix calculation power, making it easy to use by both expert and novice users Patented CleanLaze® Technology for Laser Stabilization 175cm-1 of the Rayleigh Line (65cm-1 Option Available) Fiber Optic Coupling for Convenient Sampling Up to 4000cm-1 Raman Shift Coverage Spectral Resolution as fine as 3cm-1

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Raman SpectroscopyRaman spectroscopy is used to discern the vibrational and rotational states of molecules and hence the chemical composition of a sample by measuring the inelastic scattering of monochromatic light. Explore a range of Raman spectrometers, including handheld/portable Raman spectrometers for QC/QA labs and in situ spectrometers for processes. Conduct Raman imaging for microanalysis of mixed samples using a Raman microscope. Raman spectrographs are also available. Find the best Raman spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Active PharmaceuticalsThe Active Pharmaceutical Ingredient (API) of a drug is the component that causes the direct effect of the product. The remaining inactive components are known as excipients.
Quantitative Analysis of APIs in Blending Mixtures and Tablets