ResourceSpectroscopy
Quantitative Analysis of APIs in Blending Mixtures and Tablets
12 Aug 2014This application note demonstrates that Raman spectroscopy with chemometrics can be used to develop a quantitative method to measure the concentration of APIs such as Naltrexone HCl in blending mixtures and final product tablets. The method provides quick predictions of API concentrations in blending mixtures, allowing for use in the on-line monitoring for blending processes. The high sensitivity, high resolution, and stability of the i-Raman Plus instrument conform to the requirements in developing reliable quantitative Raman analysis methods.
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Raman SpectroscopyRaman spectroscopy is used to discern the vibrational and rotational states of molecules and hence the chemical composition of a sample by measuring the inelastic scattering of monochromatic light. Explore a range of Raman spectrometers, including handheld/portable Raman spectrometers for QC/QA labs and in situ spectrometers for processes. Conduct Raman imaging for microanalysis of mixed samples using a Raman microscope. Raman spectrographs are also available. Find the best Raman spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Active PharmaceuticalsThe Active Pharmaceutical Ingredient (API) of a drug is the component that causes the direct effect of the product. The remaining inactive components are known as excipients.
