PDX dispatch: Acute myeloid leukemia PDX models
3 Jul 2025Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults, characterized by chromosomal abnormalities and gene mutations. AML develops through the gradual accumulation of mutations.
Explore how Crown Bioscience has developed a series of AML PDX tumor models that house a variety of disease subtypes and genetic features to support preclinical evaluation of new therapies or combination therapies, and a better understanding of resistance mechanisms.
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Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Gene Expression and Molecular CloningMolecular cloning is a set of techniques that utilizes vectors to transfer recombinant DNA into host cells and is an essential tool for investigating the expression of genes and proteins in bacterial or mammalian cells. A variety of vectors optimized for gene cloning and expression in a range of host organisms are available, alongside competent cells for genetic replication. Here, you can explore a range of molecular tools, high-quality genomic and cDNA libraries, premade clones, transformation and transfection reagents and mutagenesis or gene expression detection assays and expression arrays. Find the best gene expression and molecular cloning products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AML