ResourceLife Sciences
Patch clamp made easy
27 Nov 2020Conventional patch clamp remains the gold standard for the investigation of ion channels and is widely used in the area of drug discovery, safety pharmacology and basic research in academia and industry. The conventional patch clamp method requires skilled personnel to perform the experiments and is notoriously low throughput because only 1 cell can be recorded at a time. This short e-book is designed to give you an introduction to ion channels and the methods to record them.
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ElectrophysiologyElectrophysiology is the study of biological voltage changes, from a single ion channel through to a whole organ scale. Voltages can be measured using patch clamping, automated workstations, electrophysiology rigs or cell based assays. Specific cell lines, manipulators and microinjectors are also available for electrophysiology research.Patch ClampHigh ThroughputHigh throughput experiments allow the simultaneous processing of several samples. This parallelization reduces the cost per experiment and increases reproducibility and output volume of data.
