ResourceDrug Discovery & Development
Oligonucleotide therapeutics solution guide
5 Feb 2025Oligonucleotide therapeutics offer targeted disease treatment with rapid drug candidate development due to their ease of design and synthesis. However, their rapid degradation by nucleases poses challenges. Find out more about chemical modifications and advanced drug delivery systems (DDS) that can enhance stability and efficacy, supporting the development of next-generation nucleic acid-based medicines.
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OligonucleotidesOligonucleotides are small nucleic acid polymers, usually less than 20 bases in length. Oligonucleotides can be made via enzymatic cleavage or more commonly by chemical synthesis with polymerases. Their use includes FISH, southern blots, microarrays and as primers in PCR. High fidelity synthesis kits and detection systems are available for easy production and detection, respectively.