ResourceDrug Discovery & Development
Novel bioassays in picodroplets: Accelerating biotherapeutics discovery and development
21 Jun 2023Many current technologies used in drug discovery and preclinical development programs typically involve multi-step operations, extensive hands-on time, and lengthy liquid handling processes as well as low-throughput bioassays for functional validation and verification. In this application note from Sphere Fluidics Ltd., explore how microfluidic devices, with well-defined microchannel geometries and accurate flow control, can be used to generate uniform picoliter volume droplets (picodroplets) for use as miniaturized “test tubes” for high-throughput bioassays.
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Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.MicrofluidicsMicrofluidics is the science of manipulating small volumes of fluids in micro-sized channels. It is widely used in diagnostics, drug development, and lab-on-a-chip technologies. Microfluidic devices can enable rapid, cost-effective, and high-throughput analysis of biological samples. Browse our peer-reviewed product directory to find the best microfluidic devices, compare products, check reviews, and get pricing directly from manufacturers.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. It relies on cutting-edge technologies like high-throughput screening, artificial intelligence, and molecular modeling to accelerate the identification of drug candidates. Drug discovery plays a pivotal role in developing new therapies for diseases ranging from cancer to rare genetic disorders. Browse our peer-reviewed product directory to find the latest drug discovery technologies, compare options, check customer feedback, and get pricing directly from manufacturers.