Novel, automated, and highly selective phosphopeptide enrichment for identification and localization

15 Jan 2020

Variation in reproducibility and selectivity makes phosphopeptide enrichment one of the most challenging sample preparation steps available for LC/MS analysis. In this application note, Agilent discusses highly sensitive and automated phosphopeptide enrichment used during collision-induced dissociation (CID) experimentation.

Agilent 7900 ICP-MS

Agilent Technologies

The Agilent 7900 ICP-MS is a flexible single quadrupole ICP mass spectrometer that provides the industry’s best matrix tolerance, most effective helium collision mode, lowest detection limits, and widest dynamic range. As a result, you can be confident you are reporting accurate data every time, even at trace levels, whatever your sample types.

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6400 Series Triple Quadrupole LC/MS

Agilent Technologies

Meet your quantitative needs with triple quadrupole performance that gives you superior sensitivity, renowned reliability, and overall system robustness. Agilent 6400 Series Triple Quadrupole LC/MS Systems are proven choices for quantitative applications in: Pharmaceutical ADME/DMPK studies Biomarker validation Clinical research Food testing Forensics Toxicology Environmental analyses.

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Agilent 1290 Infinity II LC System

Agilent Technologies

The 1290 Infinity II LC System is an ultra-high performance LC that has market-leading sample capacity and is designed for the lowest dispersion for the most challenging ultra-HPLC experiments. The 1290 Infinity II LC system is designed to be both a HPLC and high-end UHPLC system in a single flow path, giving you robust and excellent performance no matter what application you are running while seamlessly integrating into your existing laboratory environment.

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Novel, automated, and highly selective phosphopeptide enrichment for identification and localization