Na<sub>V</sub>1.5-ΔKPQ late I<sub>Na</sub> current properties and pharmacology on the SyncroPatch 384i
18 Aug 2020Here Nanion Technologies GmbH, presents data collected on the Syncro- Patch 384i showing the peak and late INa current recorded from WT and NaV1.5-ΔKPQ cell lines. Peak current could be reliably recorded from both cell types. In WT cells, late INa was negligible in the absence of ATX-II, whereas the late INa from NaV1.5-ΔKPQ cells could be reliably recorded. Peak current from WT, and peak and late INa from NaV1.5-ΔKPQ was inhibited by ranolazine and mexiletine and IC50 values agreed well with the literature6.
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SyncroPatch 384
Nanion Technologies GmbHThe SyncroPatch 384 is a revolutionary automated patch clamp system combining high quality electrophysiological data acquisition and analysis with state-of-the-art liquid handling. With 384 amplifier channels and a 384-pipetting head, up to 384 cells can be recorded in parallel, resulting in a throughput of up to 20,000 high-quality data points per day.