Monitor and maintain glucose concentrations in real time

Process analytical technology (PAT) enables manufacturers to measure and control a process based on the product’s critical quality attributes (CQAs) in real time. In recent years, process Raman spectroscopy has gained popularity as a PAT tool that enables real-time monitoring and control of critical bioprocessing parameters which are key to the successful production of therapeutic drugs. Implementing PAT tools in biopharmaceutical manufacturing continues to receive much interest, allowing rapid development and access to therapeutics and existing medications without compromising high quality.

In this study, the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer with Thermo Scientific™ Lykos™ PAT Software and Thermo Scientific™ TruBio™ 6.0 Bioprocess Control Software was used to provide in-line feedback control of glucose in both Fed-Batch and Perfusion CHO cell culture processes without the need for operator intervention.