Measuring size, concentration, and zeta potential of LNPs with the DynaPro ZetaStar
3 Feb 2025Microfluidic formulation of RNA-containing lipid nanoparticles (LNP-RNA) is a common means of developing and producing this important non-viral modality of gene delivery. A key challenge during formulation is the selection of the specific lipids and formulation conditions to achieve the desired particle sizes and surface potential. Discover how by using the DynaPro™ ZetaStar™ instrument, researchers can rapidly characterize size, polydispersity, and zeta potential, comparing outcomes from two LNP formulation techniques to optimize efficiency and performance.
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DynaPro ZetaStar™ Dynamic, Electrophoretic, and Static Light Scattering Detector
Waters | Wyatt TechnologyUnique among its peers, the DynaPro ZetaStar™ performs simultaneous dynamic and static light scattering or dynamic and electrophoretic light scattering (DLS/SLS/ELS) measurements all within one instrument. Measure manually with microcuvettes, or automatically via an autosampler and flow cell. Quickly assess size, polydispersity, zeta potential, charge, particle concentration, molar mass or turbidity for characterization and stability studies. Key Features: DYNAMICS Touch on-board app for walk-up, self-guided operation Adaptive collection for faster and simpler measurements of zeta potential Measure size and turbidity with just 2 µL of solution, or zeta potential with as little as 65 µL of solution Measure zeta potential in buffers with conductivity up to 2x physiological saline A selection of high-quality quartz and disposable cells and cuvettes for both size and zeta potential measurements.