Managing impurities in pharmaceutical manufacturing
7 Aug 2025Impurities in pharmaceuticals can compromise patient safety — causing increased cancer risk, unpredictable adverse effects, or reduced therapeutic efficacy. However issues with forced degradation studies arise from undefined endpoints resulting in inconsistencies in both design and interpretation.
Explore this resource as it responds to this commonly faced challenge by acting as a practical companion, to existing regulatory guidance, and discusses how recent advances in analytical science can be used for reliable quantification of impurities at trace levels, helping ensure the design and manufacture of safer medicines.
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Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.OxidationImpurities