ResourceDrug Discovery & Development
LC-UV-MS-based Synthetic Peptide Identification and Impurity Profiling Using the ACQUITY QDa Detector with ProMass Software
30 Nov 2017Impurity profiling and mass confirmation of synthetic peptide-based drugs are required to ensure product efficacy and safety. This application note demonstrates the cost-effective LC-UV-MS-based workflow using ProMass and ACQUITY QDa detector for peptide identification and impurity profiling.
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Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.Sample ManagementSample management systems include sample storage devices such as freezers and plate storers, sample environment enclosures and sample organization, retrieval and sorter systems. Useful system features include high-throughput, automation, robotic arms, automated liquid handling and associated database systems. Accessories in sample management include barcode scanners, heat sealers and tubes.


