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Large scale magnetic separation for the purification of mAbs directly from cell culture

MAGic BioProcessing
12 Sept 2025

Chromatography remains central to downstream bioprocessing, especially in monoclonal antibody (mAb) production, where clarified cell cultures are essential to prevent interference with packed beds. As upstream intensification drives higher cell densities, traditional clarification methods such as centrifugation and filtration have become costly bottlenecks, adding complexity without directly contributing to product purity or concentration.

Discover how scalable magnetic separation technology offers a transformative alternative. By combining clarification and capture into a single step, it streamlines workflows, conserves resources, and boosts yield to empower researchers to rethink efficiency in advanced biomanufacturing.

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MAGic™Accio System Process

MAGic BioProcessing

MAGic™Accio PROCESS are our large fully automated magnetic separator systems, made for efficient capture of 1-40 liters of MAGic™Beads magnetic beads from large volumes of complex feedstocks. During the production phase of biopharmaceuticals, large-scale recovery of the product from an unclarified cell-culture is performed in a one-step clarification and purification by using the proprietary designed MAGic™Accio PROCESS units together with our MAGic™Beads. The magnetic separators are capable to capture up to 40 liters of MAGic™Beads at high flow rates making them suitable to process up to kilograms of proteins or antibodies per purification cycle and fully integrated in existing manufacturing workflows.

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MAGic™ Beads Protein A

MAGic BioProcessing

MAGic™ Beads Protein A offer one-step clarification and capture of monoclonal antibodies, eliminating the need for centrifugation, depth filtration and Protein A affinity column-chromatography. Super-paramagnetic porous beads coupled with an alkali resistant Protein A ligand.

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Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Magnetic BeadsMonoclonal AntibodiesMonoclonal antibodies (mAbs) are lab-made molecules that can bind to specific antigens on cells, making them highly effective in treating cancers, autoimmune diseases, and infections. These targeted therapies are transforming the treatment landscape for many conditions. Browse our peer-reviewed product directory to find monoclonal antibodies for research and clinical applications; compare products, check reviews, and get pricing directly from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.

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