Karl Fischer titration for pharmaceuticals
5 Sept 2025Precise water analysis is vital for regulatory compliance and ensuring the safety and performance of pharmaceutical products. Karl Fischer (KF) titration is the reference method for water content determination due to its high selectivity for water and governed by USP and Ph. Eur. guidelines.
Discover how to apply volumetric KF titration to measure pharmaceutical water content from 100 ppm to 100% to follow USP and Ph. Eur. standards.
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TitrationTitration is an analytical technique for determining substance concentration in a solution. For titration consider a manual or automated system, volumetric or coulometric reagent addition and indication by a potentiometer, spectrometer, turbidometer or by the Karl Fischer method. Other features of titration to consider include burettes, reagents, concentration range, reaction time and autosamplers.Drug ManufacturingKarl Fischer