Interrogating TREX1 with the Transcreener dAMP exonuclease assay
17 Aug 2022Download this application note to find out how the Transcreener dAMP exonuclease assay is a powerful tool for the discovery of TREX1 antagonists that will accelerate efforts to validate the target pharmacologically, possibly leading to a new class of immune checkpoint inhibitors.
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Transcreener dAMP Exonuclease Assay
BellBrook LabsThe Transcreener dAMP Exonuclease Assay directly measures dAMP produced by exonuclease enzymes as they cleave polynucleotides.
Transcreener® AMP²/GMP² Phosphodiesterase Assays
BellBrook LabsThe Transcreener® AMP²/GMP² Phosphodiesterase Assay Kit directly detects AMP or GMP produced by PDEs, ligases, synthetases, ENPP1, and related enzymes using a mix‑and‑read FP or TR‑FRET format—no coupling steps needed. Compatible with 1–1000 µM native substrates, it delivers excellent HTS performance (Z’ ≥ 0.7, ≥100 mP shift) in a one-step, far‑red fluorescence assay.