ResourceDrug discovery > Lead Discovery
Increase throughput by recording in unattended mode on the SyncroPatch384
27 Nov 2020This application note demonstrates recordings of hNaV1.5 expressed in CHO cells on the SyncroPatch 384 in unattended mode. In a 6 hour period, 10 compound plates were prepared, 10 NPC-384 chips were recorded and success rates, IC50s and Z’ values were calculated using 7 different compounds in duplicate on each plate, along with positive and negative controls.
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SyncroPatch 384
Nanion Technologies GmbHThe SyncroPatch 384 is a revolutionary automated patch clamp system combining high quality electrophysiological data acquisition and analysis with state-of-the-art liquid handling. With 384 amplifier channels and a 384-pipetting head, up to 384 cells can be recorded in parallel, resulting in a throughput of up to 20,000 high-quality data points per day.
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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High ThroughputHigh throughput experiments allow the simultaneous processing of several samples. This parallelization reduces the cost per experiment and increases reproducibility and output volume of data.ScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.