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Improving Preparative HPLC Column Lifetime in High-Throughput Open-Access Purification Environments

Phenomenex Inc

Improving Preparative HPLC Column Lifetime in High-Throughput Open-Access Purification Environments

9 Jul 2015

This application note demonstrates how a new preparative Axia column packing process and hardware design, used in conjunction with a reliable, easy-to-use guard column, the SecurityGuard PREP, can improve column lifetime and productivity in high throughput drug discovery labs. The pressure to produce larger amounts of purified drug intermediates and the subsequent drop in sample preparation can result in column decay leading to system shut down and incomplete runs.

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SecurityGuard Standard HPLC

Phenomenex Inc

SecurityGuard Guard Cartridge System Column Protection is designed to fit any manufacturers’ standard HPLC column, making it the ultimate HPLC Guard Column.   SecurityGuard Guard Cartridge System is guaranteed to extend the lifetime of your 2.0 mm, 3.0 mm, 3.2 mm, 4.6 mm, and 7.8mm ID column by capturing sample contaminants that can cause an increase in backpressure and effect baseline noise.     Features: Extends HPLC column lifetime Won’t alter chromatography Compatible with virtually all HPLC columns Easy to determine when to change cartridge Easy to use

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.PurificationPurification techniques are essential for isolating compounds of interest from complex mixtures, such as proteins, nucleic acids, and chemicals. These techniques are critical in biochemistry, drug development, and environmental studies. Explore purification systems in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.High ThroughputHigh throughput experiments allow the simultaneous processing of several samples. This parallelization reduces the cost per experiment and increases reproducibility and output volume of data.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. It relies on cutting-edge technologies like high-throughput screening, artificial intelligence, and molecular modeling to accelerate the identification of drug candidates. Drug discovery plays a pivotal role in developing new therapies for diseases ranging from cancer to rare genetic disorders. Browse our peer-reviewed product directory to find the latest drug discovery technologies, compare options, check customer feedback, and get pricing directly from manufacturers.HPLCHigh-performance liquid chromatography (HPLC) is a technique for separating, identifying, and quantifying components in mixtures. It is widely used in chemical, pharmaceutical, and environmental analysis to ensure purity and identify unknown compounds. Explore the best HPLC systems in our peer-reviewed product directory; compare products, read reviews, and get pricing directly from manufacturers.

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