ResourceDrug Discovery & Development
Hypertension as a driver of cardiovascular and renal disease
1 Sept 2025This guide from Inotiv explores the pivotal role of hypertension in the progression of cardiovascular and renal diseases, emphasizing its impact on early drug development. It introduces three translational animal models used to study primary hypertension, kidney-driven hypertension, and metabolic dysfunction. Each model is evaluated for its physiological relevance, strengths, and limitations, with guidance on selecting the most appropriate platform for specific research goals. The resource also highlights Inotiv’s expertise in custom model development and preclinical research capabilities.
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Animal ModelsThe use of non-human animals in experiments or behavorial observations. The research is conducted inside universities, medical schools, pharmaceutical companies, farms, defence establishments, and commercial facilities that provide animal-testing services to industry. It includes pure research such as genetics, developmental biology, behavioral studies, as well as applied research such as pharmaceutical testing in pre-clinical, before human, studies. RegulatoryPharmaceutical regulations impact on all areas of drug development, manufacture and control and supply. Services are provided from the early stages of drug development and clinical trials through to dossier submission, approval and marketing. Regulatory also includes submission of analytical studies from the pharmaceutical product and safety. Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Translational Research