ResourceSeparations
High-throughput monitoring of biotherapeutic critical quality attributes with high-resolution ion mobility-mass spectrometry
12 Oct 2023In this application note, MOBILion Systems demonstrates the benefit of incorporating high-resolution ion mobility (HRIM) into traditional LC-MS workflows for reproducible high-throughput targeted post-translational modifications (PTM) analysis for biopharmaceutical characterization.
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MOBILion SystemsMOBILion Systems is disrupting the separations game, enhancing the way we characterize biotherapeutics and identify biomarkers. Leveraging a 13-meter ion mobility path length to provide deeper level characterization without compromising time, our best-in-class SLIM-based High-Resolution Ion Mobility Mass Spectrometry (HRIM-MS) platforms separate and identify molecules that current platforms fail to detect with faster analysis and simpler workflows.
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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.
BiotherapeuticsBiotherapeutics are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or in <i>in vivo</i> diagnostics. The most well-known example of a biotherapeutic product, and the first to be approved for therapeutic use, was recombinant human insulin.