ResourceDrug Discovery & Development
Enhance your drug discovery project: Explore chemistry and navigate biology with CETSA
30 Mar 2023This eBook highlights the importance of discovering new medicines and the challenges faced in early drug discovery. It introduces CETSA® as an effective method for measuring target engagement and explains how it overcomes challenges in early drug discovery, leading to more effective lead generation and optimization. This application note also features Pelago Bioscience, a company that specializes in CETSA®, and their commitment to advancing drug discovery through engagement with science.
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Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.Lead OptimizationLead optimization is a phase in the drug discovery process. A lead is a compound that has demonstrated desired biological effects on a target. Optimization involves making chemical modifications to the structure in order to generate analogues of the original compound, which have higher potency and safety profiles.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. It relies on cutting-edge technologies like high-throughput screening, artificial intelligence, and molecular modeling to accelerate the identification of drug candidates. Drug discovery plays a pivotal role in developing new therapies for diseases ranging from cancer to rare genetic disorders. Browse our peer-reviewed product directory to find the latest drug discovery technologies, compare options, check customer feedback, and get pricing directly from manufacturers.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.