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Master EAD fragmentation for comprehensive characterization of next-gen protein therapeutics

SCIEX
6 Mar 2025

Find out how a groundbreaking electron-activated dissociation (EAD) approach can deliver deeper insights into complex therapeutics, including enhanced isomer identification, glycosylation profiling, and post-translational modification (PTM) analysis.

This SelectScience® application eBook covers:

  • How EAD is a step change in fragmentation technology
  • Enhanced peptide mapping with collision-induced dissociation (CID) & EAD
  • Streamlined single-injection middle-down workflow
  • High sequence coverage & confident PTM analysis
  • Characterization of O-linked glycosylation
  • Enhanced sequence variant analysis

Discover advanced techniques in protein therapeutic development to optimize outcomes and overcome key challenges by downloading your free copy today.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Discovery SoftwareComputational techniques used in both the chemistry and biology aspects of drug discovery, for data acquisition, processing and storage. Software is used for analysis of pathways, target identification, genomics, proteomics, modelling, lead identification, compound analysis and drug modelling among many others. Protein CharacterizationBiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.

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EAD fragmentation for characterization of next-gen protein therapies