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Driving precision oncology with chemagic technology

Revvity
27 Sept 2024

Despite its great value as a biomarker, extracting and purifying circulating free DNA (cfDNA) has traditionally posed challenges due to its low concentration and high level of fragmentation within the bloodstream. Revvity’s chemagic™ technology promises to offer a robust solution to address these challenges. Leveraging M-PVA magnetic bead technology to extract cfDNA from large plasma volumes, the DNA extraction and purification platform is designed to maximize yield and purity. When combined with advanced quantification technology such as Droplet Digital™ PCR (ddPCR), the workflow provides precision and repeatability in early cancer biomarker research.

In this case study, Revvity explores how chemagic DNA extraction and purification technology is helping to optimize results.

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chemagic 360

Revvity

The chemagic™ chemagic 360 instrument is a flexible compact solution for automated nucleic extraction from diverse sample materials.

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DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. Consequently, the importance of high-quality DNA/RNA extraction and purification equipment cannot be underestimated. Many purification kits are available and are typically optimized for nucleic acid type and source, including plasmid DNA, genomic DNA, mRNA, RNA and viral nucleic acid purification kits. Automated extraction and purification of nucleic acids can be implemented with magnetic bead separator instruments or high-throughput purification workstations. Find the best DNA/RNA extraction and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Liquid BiopsiesLiquid biopsies are non-invasive tests used to detect cancer and other diseases by analyzing blood or other bodily fluids. This technique is gaining popularity for early detection, monitoring treatment response, and detecting minimal residual disease. Explore liquid biopsy solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.cfDNATumor MarkersCLINICAL24CLINICAL24 is a global conversation, hosted by SelectScience for the medical laboratory profession and all those that support it. The purpose of CLINICAL24 is to highlight current lab challenges, and to explore the technology solutions to overcome them.

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