Developing therapeutic antibodies: What do bispecific antibodies and the Trojan Horse have in common?

Bispecific antibodies (bsAbs) are a versatile class of targeted therapeutics designed to bind two different sites, which can be located either on a single antigen or on two antigens. However, many traditional technologies for characterizing them efficiently are limited in their ability to provide a quantitative functional assessment of two interactions to one bispecific molecule. Furthermore, commonly used assay platforms such as ELISA and SPR are time-intensive. In this eBook, ForteBio provides insight into how to overcome development challenges, an easy quantitative approach to assess bispecific interactions in a versatile, label-free, and easy-to-use format, and solutions from its customers working in the field of engineering bsAb as next-generation therapeutics.