ResourceSpectroscopy

Color analysis for pharmaceutical products using UV-Visible absorption techniques

14 Mar 2024

In this application note, Thermo Fisher Scientific explores how the ability to detect subtle changes in color is crucial in pharmaceutical manufacturing for quality analysis. Variations in color may indicate impurities or degradation in the product, especially for substances prone to decomposition. While qualitative comparison against a standard is common, environmental factors and subjective differences pose challenges. Therefore, spectroscopic measurements, particularly using UV-Visible spectrophotometry, offer a quantitative approach. Overall, color analysis, coupled with advanced spectroscopic techniques, offers a robust approach to pharmaceutical quality assessment, applicable to both liquid and solid samples, and compliant with regulatory standards.

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UV-Visible SpectroscopyUltraviolet-visible (UV-Vis) spectrophotometers are used to measure the interaction of UV and visible light with a sample, including transmission, reflectance & absorbance. The two major instrument classes are single-beam or double-beam spectrophotometers. More specialized equipment includes colorimeters, spectroradiometers and refractometers. Portable and microvolume spectrophotometers are also available. For the modular spectroscopy lab, explore a range of light sources for combination with a spectrograph/spectrometer and optics. Find the best UV-Vis spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.Environmental Monitoring and TestingEnvironmental monitoring and testing uses handheld portable analyzers, kits, spectrometers or chromatography systems for air, water, soil, food and other sample testing. Useful features of analyzers such as BOD and COD include portability, easy calibration, automation and sensitivity.  Environmental test kits for pH, water, moisture, etc, should be accurate, sensitive, reliable, fast and easy to use.Food and Beverage AnalyzersFood and Beverage Analyzers are commonly used to provide information about the chemical composition, structure and physical properties of food materials.Environmental AnalysisEnvironmental analysis describes a variety of tests that determine the effect of chemicals, processes and particulates such as persistent organic pollutants (POPs) have on the environment.UVUltraviolet (UV) light is used in a variety of applications, including disinfection, spectrophotometry, and molecular biology. UV light can damage DNA, making it a powerful tool in sterilization and in studies of mutagenesis and gene repair. Explore UV-related products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Sample ProcessingSample processing is required to prepare samples prior to analysis. Technologies used for sample processing include homogenizers, grinders, mills and mixers.SpectrophotometrySpectrophotometry is a technique used to measure the absorption or transmission of light through a sample. It is commonly used in chemical analysis, environmental monitoring, and quality control. Explore spectrophotometry tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.
Color analysis for pharmaceutical products using UV-Visible absorption techniques