ResourceDrug Discovery & Development
Case study on the determination of the acid dissociation constant
9 Oct 2025The determination of the acid dissociation constant (pKa) is an important step in the development of new pharmaceutical products. Explore the fundamentals of pKa and how METTLER TOLEDO titrations, in combination with the LabX Titration Software, allow for the measurement to be routinely performed and the data documented and exported according to GLP.
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TitrationTitration is an analytical technique for determining substance concentration in a solution. For titration consider a manual or automated system, volumetric or coulometric reagent addition and indication by a potentiometer, spectrometer, turbidometer or by the Karl Fischer method. Other features of titration to consider include burettes, reagents, concentration range, reaction time and autosamplers.