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Building a custom biosafety cabinet around your laboratory automation equipment

NuAire, Inc.
30 Sept 2024

This whitepaper covers designing a custom biosafety cabinet (BSC) for laboratory equipment that requires primary containment. Discover how to determine if the equipment needs to be placed inside a custom BSC, the critical discussion points for custom BSC design, the physical placement of the custom BSC, and the considerations for performance testing and field certification.

by Julianne Baron, PhD, CPH, RBP

This whitepaper is shared as part of the global #CLINICAL24 conversation

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AutoLabGard ES NU-125 Mini-Room Class II, Type A2 Biosafety Cabinet

NuAire, Inc.

The AutoLabGard ES (Energy Saver) NU-125 Mini-Room is designed after a Class II, Type A2 Biological Safety Cabinet on a larger scale to provide Class II protection for personnel, product, and the environment. The mini-room can be used for applications involving high-throughput robotic systems, large high-speed cell sorters, ultra-centrifuges, and laboratory equipment requiring Class II protection from potentially harmful aerosols and airborne particles. The NU-125 AutoLabGard ES is constructed with an interior stainless steel floor and wall panels that are gasketed and bolted together. Painted exterior Cold Rolled Steel (CRS) cover panels are gasketed and bolted to the stainless wall panels that make up the negative pressure plenum. Painted CRS blower modules are mounted on top of the wall panels and contain both the supply and exhaust HEPA filters along with the ultra-high efficiency DC ECM motors. Stainless steel doors complete the cabinet enclosure with a hinged window assembly mounted on each door providing an 8 inch (203mm) access opening. If additional access is needed to the interior for user or system interfaces (i.e. power/computer cables, process tubing, etc.), negative pressure pass through ports may be added to the sides or rear of the enclosure that maintain enclosure containment. The airflow pattern of the NU-125 AutoLabGard ES is identical to any class II, type A2 biosafety cabinet. Room air is pulled into the cabinet through the work access opening at an average velocity of 105 fpm (.53 m/s) to provide an air barrier. Engineered with an ultra-high efficiency motor the AutoLabGard lowers operating costs by using less electricity and increasing filter life with less heat output. Each NU-125 is tested and comes with a certified copy to tests consistent with standard NSF/ANSI 49. Contact NuAire today to start your high-throughput robotic system enclosure consultation. Example Application: A perfect match for the BD FACS Airflow Cytometer Laboratory equipment or processes requiring sterility Class II Biological Safety Cabinet protection for robotics

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Automation Supplies / AccessoriesAutomated accessories and consumables make lab processes fast, efficient and reliable. Useful automation accessories include microplate sealers, label printers and reagent reservoirs.Fumehoods and Biological Safety CabinetsFume hoods and biological safety cabinets are used to provide personnel, sample and environmental protection by limiting exposure to hazardous materials either by venting or enclosing hazardous sample space. Fume hoods include filtered and ductless fume hoods, general ducted fume hoods, laminar flow cabinets and cabinets for powder weighing. There are three classes of biological safety cabinet, dependent on the level of protection provided. Class I provide personnel and environmental protection, class II provide product, personnel and environmental protection. Class III provide the highest level of protection and are designed for use with high-risk biological agents. Other ventilated workspaces for the laboratory include glove boxes, glove bags, anaerobic and hypoxic workstations. Find the best fume hoods and biological safety cabinets in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AutomationAutomation in laboratories and manufacturing processes enhances efficiency, precision, and scalability by reducing the need for manual intervention. It plays a critical role in improving productivity, minimizing human error, and accelerating workflows in fields like diagnostics, drug development, and industrial testing. Automation technologies include robotic systems, automated liquid handlers, and process control systems that streamline complex tasks and ensure consistent, reproducible results. Explore our peer-reviewed product directory to discover the best automation solutions, compare options, read user reviews, and get prices directly from manufacturers.Clinical AutomationClinical laboratory automation refers to the use of automated systems in clinical laboratories to increase efficiency, reduce human error, and improve patient care. From sample analysis to total laboratory automation, this plays a critical role in modern diagnostics and laboratory workflows. Explore clinical automation solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.CLINICAL24CLINICAL24 is a global conversation, hosted by SelectScience for the medical laboratory profession and all those that support it. The purpose of CLINICAL24 is to highlight current lab challenges, and to explore the technology solutions to overcome them.

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