Biocompatibility studies on CHO cell culture in X-ray irradiated BioBLU Single-Use Bioreactors

The potential leakage of toxic or inhibitory chemicals from plastic materials from single-use bioreactors is increasingly known within cell culture. Leachables are particularly problematic, as they can migrate from the plastic into the process fluid under process conditions and can inhibit cell growth or affect the final product quality. By strictly adopting the 'DECHEMA Recommendation for Leachables Studies – Standardized cell culture test for the early identification of critical films', Eppendorf demonstrates the absence of negative impacts caused by leachable compounds from the X-ray irradiated material on growth, viability, and metabolic profile of the CHO cell line tested.