Automated high-throughput polymorph/crystallization screening through Kapton plates

During the crystallization process, an organic molecule can adopt more than one crystalline form. Morphology and particle size distribution are important solid-state characteristics; however, uncontrolled occurrences of multiple physical forms of APIs can have significant effects on the performance of the material during processing, manufacturer storage, and administration of the drug.

In this application note, Thermo Fisher Scientific demonstrates a workflow for high-throughput polymorph screening using its DXR3 SmartRaman Spectrometer.