Analysis of VOCs in Exhaled Breath as Cancer Biomarkers

14 Jul 2014

Characteristic odors in breath have long been used as a tool for medical diagnosis. SPME with GC-MS analysis showed that the VOC profiles between a small set of healthy individuals and those diagnosed with lung cancer were significantly different.

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SPME-LC Fiber Probe
Sigma-Aldrich Supelco
The SPME-LC fiber probes are intended as single-use devices for the extraction of small molecules out of a fluid followed by solvent desorption and LC analysis.Traditional solid phase microextraction (SPME) fibers were developed with common GC type phases, which were primarily designed for extraction of volatile or semi-volatile compounds using thermal desorption as the means of introducing sample into the chromatographic column.The newly developed fiber probes contain C18 silica particles embedded in a proprietary, non-swelling, biocompatible polymer. The benefit of this design enables minimized binding of macromolecules such as proteins and phospholipids, but allows extraction of most smaller analytes of interest.The fiber core is made from a flexible metal alloy with shape memory properties and a diameter larger than typical SPME fibers. The larger diameter enables the fiber to be used both as the plunger and fiber core, thus simplifying the device construction and reducing the cost of the probe. The fiber is also sealed into a hypodermic needle with an attached hub to allow movement of the fiber for exposure and retraction into the needle.
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SPME-Fast Fit Fiber Assemblies (FFA)
Sigma-Aldrich Supelco
A new generation of SPME products.The Fast Fit Fiber Assemblies were developed by Chromline srl Prato Italy in cooperation with Supelco expanding the applicability of SPME for rapid sampling and analysis using multiple fiber assemblies. This product line is centered around the barcoded SPME Fast Fit Assemblies that can be automatically exchanged on a CTC CombiPAL type autosampler equipped with the Multi Fiber EXchanger (MFX) system.This offers a range of beneficial options:• Automatically desorb multiple SPME-FFAs loaded with, for example air samples collected using the SPME-Diffusive Sampling Holder (DFH) or the SPME-FFA Field Sampler (FFA-FS)• No manual switching out of the fiber when performing extractions with a selection SPME phases to quickly screen for optimal phase selectivity in SPME method development.• Enhance analyte polarity range as a result of extracting the same sample with different SPME fiber phase selectivities.• Program longer unattended GC/MS autosampler sequences.
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Polydimethylsiloxane/Divinylbenzene (PDMS/DVB) SPME Fibers
Sigma-Aldrich Supelco
Polydimethylsiloxane/Divinylbenzene (PDMS/DVB) SPME Fibers.Solid Phase Microextraction (SPME) is an innovative, solvent-free sample prep technology that is fast, economical, and versatile. SPME uses a fiber coated with a liquid (polymer), a solid (sorbent), or a combination of both. The fiber coating removes the compounds from your sample by absorption in the case of liquid coatings or adsorbtion in the case of solid coatings. The SPME fiber is then inserted directly into the chromatograph for desorption and analysis. SPME has gained wide spread acceptance as the technique of preference for many applications including flavors and fragrances, forensics and toxicology, environmental and biological matrices, and product testing to name a few.
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Polydimethylsiloxane (PDMS)- non-polar SPME Fibers
Sigma-Aldrich Supelco
Polydimethylsiloxane (PDMS)- non-polar SPME Fibers.Solid Phase Microextraction (SPME) is an innovative, solvent-free sample prep technology that is fast, economical, and versatile. SPME uses a fiber coated with a liquid (polymer), a solid (sorbent), or a combination of both. The fiber coating removes the compounds from your sample by absorption in the case of liquid coatings or adsorbtion in the case of solid coatings. The SPME fiber is then inserted directly into the chromatograph for desorption and analysis. SPME has gained wide spread acceptance as the technique of preference for many applications including flavors and fragrances, forensics and toxicology, environmental and biological matrices, and product testing to name a few.
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