Oligonucleotides > Services Products & Reviews

For the Roche Digital LightCycler® System

Double-stranded DNA fragments for high-throughput screening applications

The Agilent SurePrint platform delivers high-quality oligo pools perfectly suited for applications in protein engineering, gene assembly, pooled CRISPR screening, and more. Agilent oligo pools offer custom, high resolution, massively parallel DNA synthesis available in standard or HiFi options in a broad range of sizes.

Oligonucleotide GMP manufacturing for human therapeutics

If you commercialize Molecular Diagnostics (MDx), create Laboratory Developed Tests (LDTs), or conduct preclinical research, then your final kit, assay, or modality must have an extraordinary level of quality to comply with strict regulatory or study standards. In the case of oligonucleotide raw materials available with custom specifications, the only option you should consider is Custom cGMP Oligos.

Creative Biolabs delivers an end-to-end CAR-T development pathway—from target/scFv discovery, CAR design and vectoring, and cell engineering to in-vitro/in-vivo efficacy, IND authoring, and manufacturing support. Modular and GMP-aligned, the platform spans autologous and allogeneic routes (incl. TRAC/Cas9 and mRNA) to de-risk translation for hematologic and solid tumor programs.

End‑to‑end solid‑tumor CAR‑T development—from antigen/scFv discovery and CAR optimization to cell engineering, in‑vitro/in‑vivo efficacy, and IND support. Incorporates dual/logic‑gated and armored CARs, plus trafficking and persistence enhancements to overcome the tumor microenvironment and improve safety and translation.

Tailored formulation and conjugation for nucleic acids and biologics, covering LNPs and alternative carriers, ligand-directed strategies (e.g., GalNAc), and full characterization and process development to enhance stability, targeting, and potency with documentation for scale-up and regulatory needs.

Custom DNA/RNA oligonucleotide synthesis with broad modification choices (PS, 2′-OMe, 2′-F, LNA, GalNAc, dyes/biotin), multiple scales and purifications, and analytical QC. Includes design consultation and documentation to support research, translational studies, and conjugation-ready formats.

Integrated ASO development from sequence design and chemistry selection to preclinical PK/PD, safety, delivery (e.g., GalNAc), and CMC—supporting gapmer and steric-blocker approaches to advance programs efficiently toward IND.

End‑to‑end allogeneic cell therapy development—covering donor strategy, multiplex genome editing for safety/immune evasion, scalable manufacturing and comparability, and IND/CMC support—across CAR‑T/CAR‑NK and other donor‑derived modalities to enable off‑the‑shelf access.

Comprehensive circRNA services including design, circularization (e.g., ribozyme/intron-mediated), purification, and analytics to deliver stable, translation-competent RNA with improved durability—supported by process development for research and translational programs.

End-to-end viral vector design and construction covering vector/serotype selection, expression-cassette optimization, cloning, packaging, purification, and QC. Supports AAV, lentivirus, adenovirus, HSV, vaccinia, and baculovirus with scalable production and documentation for in vitro/in vivo studies and IND-enabling work.

Stable Isotope-labeled Standards for Glycan Research

High-quality and cost-effective custom RNA oligos up to 266 nt, featuring comprehensive modifications.

Stable Isotope-labeled RNA and DNA Products

High-quality and cost-effective custom DNA oligos up to 218 nt, backed by over 22 years of experience.

Our Metabolite Identification service employs HRMS /LC-MS/MS to decode degradation pathways of antisense oligonucleotides (ASOs), siRNAs, and modified variants, identifying chain-shortened metabolites (5’/3’ cleavage), phosphorothioate changes (desulfurization, inversion) and base/nucleotide alterations (deamination/depurination). Through plasma/tissue/cell analysis, we reveal metabolic stability, biodistribution, and exonucle…

The oligos are made to your specifications, with rigorous quality control, and quick turnaround for use in a variety of applications, including PCR, cloning, sequencing, and gene detection. Use the improved ordering portal to place your orders.  

Complete synthetic genes with 100% sequence verification are provided in a plasmid cloning vector and ready to use in a variety of applications.

Double-stranded DNA fragments for quick and cost-effective cloning

High fidelity, sequence verified, Double-stranded DNA fragments for large gene construction

Semiconductor-based 8 million oligos per chip with superior precision and consistency.

Custom DNA oligos—manufactured and shipped the same day you order

For routine applications, Bioneer offers standard custom oligos with no modification, Bio-RP purification, provided in a tube format. The chart in the ordering information tab shows pricing at various synthesis scales, but please contact your sales representative to learn about any institutional or volume discounts we might have in place for our oligonucleotides.