Enzymes > Nuclease Products & Reviews

Recombinant, high-purity endonucleases for genome editing experiments

Type III-A, ≥85% RNase A basis (SDS-PAGE), 85-140 Kunitz units/mg protein

resDetect™ DNase Activity Assay Kit (Fluorescence) uses the FRET method to detect DNase in buffers, reagents, and other components within 30 minutes. It offers a rapid, sensitive, and quantitative tool for identifying DNase contamination. Additionally, the DNase and RNase Activity Assay Kit enables simultaneous quantitative detection of DNases and RNases in a single assay.

Salt Active Nuclease High Quality (SAN HQ) is a Bioprocessing Grade nuclease available in GMP grade developed as the most efficient solution for removal of both single and double stranded DNA and RNA at high salt conditions(400–700 mM). It excels in DNA removal for robust viral vectors like Adenovirus and AAV, ensuring superior product purity while improving DSP. Ideal for gene therapy and vaccine manufacturing. Triton free av…

resDetect™ RNase Activity Assay Kit (Fluorescence) uses the FRET method to detect RNase in buffers, reagents, and other components within 30 minutes. It offers a rapid, sensitive, and quantitative tool for identifying RNase contamination. Additionally, the DNase and RNase Activity Assay Kit enables simultaneous quantitative detection of DNases and RNases in a single sample.

Double-Strand Specific dsDNase from ArcticZymes is ideal for removing contaminating DNA from PCR master mixes, preventing false positives in bacterial typing. Recombinantly produced in Pichia pastoris, it cleaves dsDNA with 5000-fold higher specificity than ssDNA. Easily inactivated by moderate heat (65°C), it allows for direct addition of DNA templates post-cleanup, ensuring accurate PCR results.

HL-SAN efficiently removes nucleic acids from buffers in protein purification, excelling in high-salt conditions to reduce aggregation. Ideal for removing nucleic acids from proteins with high DNA/RNA affinity, it performs well during lysis, early purification stages, and high-salt eluates. This cold-adapted enzyme works effectively at ambient temperatures and during overnight digestion at 4°C. Triton free available.

Nonspecific endonuclease is highly active at physiological conditions (125–200 mM) for DNA removal during protein production, vaccine manufacturing, and viral vector preparation. M-SAN High Quality can be used directly in cell media, which improves efficiency and yield. Designed to replace Benzonase without workflow changes. M-SAN HQ excels in ensuring higher purity and efficiency. High purity (≥ 99%). Compatible with ELISA ki…

HL-dsDNase efficiently removes genomic DNA from RNA with minimal impact on RNA quality, reducing 50 ng of gDNA to undetectable levels by qPCR. Easily inactivated by 5-minute incubation at 58°C, it’s ideal for RNA prep, minimizing degradation. It's also effective for removing external DNA from samples before metagenomic sequencing and STR-profiling, for fast, efficient alternative to traditional methods. Triton free available.

DNA fragmentation

Complete digestion of DNA into individual nucleosides.

99% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution, ultrapure grade

lyophilized powder, Protein ≥85 %, 

lyophilized powder, ≥200 units/mg protein (E1%/280, 3′-5′-Phosphodiesterase)

for molecular biology, ≥70 Kunitz units/mg protein, lyophilized

from bovine pancreas

DNase I, (RNase-free) is an endonuclease that nonspecifically cleaves DNA to release di-, tri- and oligonucleotide products with 5´-phosphorylated and 3´-hydroxylated ends (1,2). DNase I acts on single- and double-stranded DNA, chromatin and RNA:DNA hybrids.

A DNA-free option for Cas9 nuclease expression

A DNA-free option for Cas9 nuclease expression  

Lentiviral CRISPR-Cas9 components for robust gene editing in biologically relevant cell types

Point, click, edit. Guaranteed.

Recombinant, high-purity endonucleases for genome editing experiments

Recombinant, high-purity endonucleases for genome editing experiments

Recombinant, high-purity endonucleases for genome editing experiments

Recombinant, high-purity endonucleases for genome editing experiments