ADME-Toxicology Products & Reviews

The Promega CytoTox 96® Non-Radioactive Cytotoxicity Assay is a colorimetric alternative to radioactive cytotoxicity assays. The CytoTox 96® Assay quantitatively measures lactate dehydrogenase (LDH), a stable cytosolic enzyme that is released upon cell lysis, in much the same way as [51Cr] is released in radioactive assays. Released LDH in culture supernatants is measured with a 30-minute coupled enzymatic assay that result…

The GSH-Glo™ Glutathione Assay is a luminescence-based assay for the detection and quantification of glutathione (GSH). The assay is based on the conversion of a luciferin derivative into luciferin in the presence of glutathione, catalyzed by glutathione S-transferase (GST). The signal generated in a coupled reaction with firefly luciferase is proportional to the amount of glutathione present in the sample. Luminescence is gen…

ADAM SCC2, a fast, easy and accurate automated somatic cell counter, is composed of fluorescence optic and image analysis software. It can be useful equipment for dairies, smaller labs and veterinary establishments working with somatic cell analysis. It is helpful to the implementation of milk quality control.

ADAM SCC is fully compatible with the Direct Microscope Somatic Cell Count (DMSCC) with the unique image cytometer technology.

CN Bio supports non-alcoholic steatohepatitis (NASH) therapeutic development via fast-track NASH Contract Research Services. NASH Services enable you to gain instant access to CN Bio’s expertise and one of the most advanced human in vitro models available. Submit lead candidates for screening and receive human translatable data for insightful preclinical candidate prioritization, clinical trial design and optimization.

CN Bio supports R&D efforts via fast-track Drug Metabolism and Safety Toxicity Testing Services that deliver human translatable insights from lead candidates in a few weeks and at lower cost than animal studies. By accessing the Company’s expertise and advanced in vitro liver-on-chip models, these Services enable researchers to step beyond standard in-house laboratory workflows for better informed pre-clinical decisions.

We offer extensive Antibody Functional Characterization Services, focusing on both Fab-based target binding and Fc-mediated effector functions. Our assays analyze mechanisms like Neutralization, ADCC, CDC, and ADCP, leveraging advanced platforms to select promising therapeutic candidates.

Creative Biolabs provides comprehensive PK/PD studies for nonclinical drug evaluation (determining efficacy, safety, dosing). Key features: vast disease models (oncology, neurology, etc.), advanced model tech (CRISPR, humanized mice), integrated PK/PD/safety analysis, and global scientific consultation.

ARRALYZE 8 Chamber Slide combines standard slide format with advanced nanowell technology, featuring 8 chambers with 127 precisely etched nanowells (0.4 × 0.4 × 0.225mm) per chamber. The borosilicate glass bottom (0.175μm thick under wells) provides superior optical clarity for high-resolution imaging while maintaining an inert environment. Includes 3 fiducials per chamber for easy navigation and precise cell tracking.

Simplify your omics research

Resolve cross-functional pathways

Accelerate Drug Discovery with Crown Bioscience's Comprehensive DMPK / ADME Services

The only kit you’ll need to build your own organ-on-chip

Our Metabolite Identification service for peptides utilizes HRMS to characterize peptide metabolism (e.g., hydrolysis, oxidation, glucuronidation). The assay identifies and semi-quantifies metabolites in plasma/tissues, enabling ADME profiling (clearance, bioavailability), toxicity screening (reactive metabolites) and peptide optimization (PK/PD enhancement). Integrated with preclinical data, it supports metabolically stable p…

Kits to covalently label dead cells, allowing cells with permeable plasma membranes to be excluded from analysis in flow cytometry. A wide variety of dye options for standard flow, spectral flow, and fluorescence microscopy.

For Use in Metabolomics Applications Ranging from Quality Control to Quantification

The new standard of excellence in quantitative metabolomics profiling

Pion’s PAMPA high-throughput permeability assay uses a range of membranes to mimic physiologic conditions. It allows you to evaluate the passive permeability of API’s as well as the absorption potential of simple or complex formulations using robust models and protocols in a 96-well format.

The open organ-on-chip platform

Unraveling the complexity of disease

A focused set of recombinant immune regulatory proteins, such as PD-1, PD-L1, and CTLA-4, essential for research and drug discovery in cancer immunotherapy and autoimmunity.

Recombinant proteins specifically relevant as E3 ligases or target proteins for Proteolysis Targeting Chimeras (PROTACs), enabling the development of this novel targeted protein degradation technology.

Transforming medicine with metabolomics

Fujifilm Wako has developed the MassivEV™ EV Purification Column PS, which utilizes our proprietary EV isolation and purification technology known as the PS affinity method1). Used in conjunction with the specialized MassivEV™ Purification Buffer Set (Product Number: 295-96601), this system enables convenient isolation and purification of EVs, including exosomes, from liter-scale cell culture supernatants.

Stable Isotope-labeled and Unlabeled Metabolites and Substrates