HTS Libraries Products & Reviews

Recombinant Human B-cell lymphoma 2 (BCL-2) protein, a key regulator of apoptosis (programmed cell death) and a well-established oncoprotein in many cancers.

Recombinant Human B-cell Antigen Receptor Complex-associated protein alpha chain (CD79A), a essential component of the B-cell receptor (BCR) and a marker for B-cell lineage.

A recombinant B-lymphocyte surface antigen, CD19, which is a pivotal target for immunotherapy in B-cell malignancies, including CAR-T cell and antibody-based therapies.

Recombinant proteins specifically relevant as E3 ligases or target proteins for Proteolysis Targeting Chimeras (PROTACs), enabling the development of this novel targeted protein degradation technology.

A portfolio of recombinant immunoglobulins and cell surface proteins serving as critical targets for the development and functional validation of Chimeric Antigen Receptor T-cell (CAR-T) therapies.

Recombinant Human Leukocyte Antigen G (HLA-G), a non-classical MHC class I molecule involved in immune tolerance at the maternal-fetal interface and in immune evasion by tumors.

Recombinant Human Fibroblast Growth Factor 2 (Basic FGF), a potent mitogen and morphogen for a wide range of mesoderm and neuroectoderm-derived cells in culture.

Recombinant Human Erythropoietin (EPO), the primary hormone regulating red blood cell production (erythropoiesis), used in research and as a therapeutic for anemia.

Recombinant Human Programmed Cell Death Protein 1 (PD-1/CD279), a critical immune checkpoint receptor that suppresses T-cell activation and is a major target in cancer immunotherapy.

Vapourtec offers a range of world class peptide synthesizer systems offering fast flow solid phase peptide synthesis from 0.05 mmol to 30 mmol.

Highly diverse libraries with 95% guaranteed coverage and industry-leading acceptance rate, delivered in as little as 2 weeks

GenScript's proprietary platforms offer a wide range of ready-to-use peptides, ensuring high-quality, HPLC-purified products for fast, cutting-edge research.

Recombinant Human B-cell Maturation Antigen (BCMA/TNFRSF17), a TNF receptor superfamily member that is a clinically validated target for multiple myeloma therapies.

Highly diverse libraries with 95% guaranteed coverage and industry-leading acceptance rate, delivered in as little as 2 weeks.

EMD Millipore's hERG membrane preparations are crude membrane preparations made from HEK293 stable recombinant cell lines, which are ideal HTS tools for screening antagonists against the hERG channel. The membrane preparations exhibit a Kd of 5.2 nM for [3H]-Astemizole. With 10 μg/well hERG Membrane Prep and 3.0 nM [3H]-Astemizole, a greater than 4-fold signal-to-background ratio was obtained.

Chem-1 cells are an adherent cell line endogenously overexpressing Galpha15 that is used as a host for Chemicon's ChemiScreen™ GPCR Membrane Preparations. Chemicon's ChemiScreen™ Wild-Type Chem-1 Membrane Preparations are ideal controls for validation of radioligand binding assays employing ChemiScreen™ GPCR Membrane Preparations in the Chem-1 host cell line.

Chemicon's cloned human CXCR1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CXCR1 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CXCR1 and its ligands.

EMD Millipore's CXCR1 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of CXCR1 interaction with IL-8. The membrane preparations exhibit a Kd of 0.2 nM for [125I]-IL-8. With 5 μg/well CXCR1 Membrane Prep and 0.1 nM [125I]-IL-8, a greater than 5-fold signal-to-…

Chemicon's cloned human CXCR2-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CXCR2 expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CXCR2 and its ligands.

Chemicon's CXCR2 Membrane Preps are ideal tools for screening for antagonists of interactions between CXCR2 and its ligands. Radiolabeled IL-8 binds to the CXCR2 membranes with a Kd of 0.075 nM. With 0.1 nM 125I-labeled IL-8, a 5-fold window of specific binding is obtained.

Chemicon’s cloned human CXCR3-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CXCR3 expression on the cell surface and contains high levels of the promiscuous G protein G16 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CXCR3 and its ligands.

EMD Millipore’s ChemiScreenTM CXCR3 receptor membrane preparations are ideal tools for screening for antagonists of CXCR3 interactions with its ligands. With 0.1 nM 125I-labeled IP10, the CXCR3 membrane preparation at 5 μg/well gives a signal:bakground of greater than 10-fold.

Chemicon's cloned human recombinant CXCR4-expresssing cell lines is made in Chem-1 host, which support high levels of recombinant CXCR4 expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CXCR4 and its ligands

Chemicon's CXCR4 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal tools for screening for antagonists of interactions between CXCR4 and SDF-1a. Radiolabeled SDF-1a binds to the CXCR4 membranes with a Kd of 0.9 nM. With 0.04-0.13 nM 125I-labeled SDF-1a, an approximately 3-fold window of specific bin…

Chemicon’s cloned human CCR1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CCR1 expression on the cell surface and contains high levels of the promiscuous G protein G15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CCR1 and its ligands.