Products & ReviewLife Sciences
PD-1
Recombinant Human Programmed Cell Death Protein 1 (PD-1/CD279), a critical immune checkpoint receptor that suppresses T-cell activation and is a major target in cancer immunotherapy.
PD-1
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Description
PD-1 is expressed on activated T-cells and, upon engagement with its ligands PD-L1 or PD-L2, transmits an inhibitory signal that dampens the immune response. Blocking this interaction with checkpoint inhibitor antibodies has revolutionized cancer treatment. Our PD-1 protein is a key reagent for developing and characterizing these therapeutics.
Key Features & Benefits:
- High-Affinity Binding to PD-L1 and PD-L2
- Functional Grade for T-cell Activation Assays
- Essential for Checkpoint Inhibitor Antibody Screening
- Available as Monomer or Dimer
Relevant Applications:
- Immune Checkpoint Inhibitor Discovery and Validation
- Binding Kinetics and Blocking Assays (SPR/BLI)
- T-cell Exhaustion and Re-invigoration Studies
- Companion Diagnostic Development
