Formulation
EMPROVEĀ® exp for use as excipient As drug approval procedures grow stricter, regulatory requirements are becoming more demanding for excipients. Our high-quality EMPROVEĀ® exp raw materials for use as excipients not only comply with relevant regulations, but also come with detailed documentation, facilitating lower costs of qualification, so you can get to market faster. EMPROVEĀ® exp dossiers comprise information on the manufā¦
Excellent hardness and fast disintegration for wet granulation formulations Mannitol, a sugar alcohol that predominantly occurs in three crystalline forms (alpha, beta and delta polymorph), is especially suitable as an excipient for advanced, highly active APIs thanks to its non-hygroscopicity and low content of reducing sugars. However, standard mannitol (in beta quality) often lacks sufficient binding and compaction propertā¦
With todayās faster, leaner production requirements, the smooth integration of pharmaceutical excipients is essential. And since pharmacopeia now specify functionality in addition to chemical purity, Merck Millipore has adopted these challenges in a new addition to the ParteckĀ® family. ParteckĀ® LUB products are vegetable grades of Magnesium stearate, Calcium stearate and Stearic acid, the most effective excipients for lubricaā¦
Advanced technology for excellent tabletting properties Mannitol is a sugar alcohol that is especially suitable as an excipient for advanced, highly active APIs due to its non-hygroscopicity and low content of reducing sugars. Merck Millipore's outstanding, directly compressible mannitol ParteckĀ® M is your best choice ā especially if your tableting aims at rapid release of high-dose or low-dose actives.ParteckĀ® M belongs toĀ tā¦
ParteckĀ® Mg DC ā directly compressible without additives The efficient and safe production of tablets ā from drugs to fizzy tablets ā requires high-quality excipients, especially if higher ingredient concentrations are needed. The best choice for formulation of such drugs are excipients that are directly compressible because they make it possible to produce sufficiently hard tablets at high quality and with fewer process stepā¦
Merck Milliporeās ParteckĀ® ODT gives formulators the opportunity to produce top-quality, rapid-acting tablets more cost-effectively than ever. These days, people want no-fuss, no-wait solutions ā convenience products that work, quickly and without hassle. This is why many patients prefer orally disintegrating tablets, or ODTs.ODTs allow manufacturers to provide fast-acting medication, add value to existing compounds and ā impā¦
Unique functional particles for excellent tabletting properties ParteckĀ® SI, Merckās outstanding, directly compressible sorbitol, is available in a variety of particle sizes and qualities for virtually any application you can imagine.The unique particle structure of ParteckĀ® SI ā loosely packed, needle-like crystals ā gives it some quite distinctive physical properties making ParteckĀ® SI the perfect excipient for combining maā¦
Optim is an innovative analytical instrument designed to probe multiple protein stability-indicating parameters at high speed using ultra-low sample volumes of proteins and other molecules. Compact and robust, using a light scattering and fluorescence technology in a configuration never seen before and controlled by an all-new easy-to-use intuitive software package, the Optim 2 has been designed to reduce the time and cost ofā¦
An ideal choice for drug delivery. Human albumin is ideally suited as a half-life extension approach for protein drugs. It is a natural, non-immunogenic plasma carrier protein which is extremely stable, highly soluble and large enough to avoid renal clearance. It is also widely accepted that albumin is recycled in the body, due to its interaction with its receptor, known as the neonatal Fc receptor (FcRn). FcRn is present onā¦
Recombinant albumin developed as an excipient for use in drug delivery and formulation. Recombumin Prime is the world's first and only supply of commercial, animal-free, recombinant human albumin, approved for use in the manufacture of human therapeutics.Used in the manufacture of the FDA and EMEA approved MMRā¢ II childhood vaccine from Merck and Co., Recombumin Prime USP-NF* is also being evaluated as an excipient, or ingredā¦
Derived from our proprietary S. cerevisiae yeast expression technology Recombumin Alpha USP-NF* has been developed to deliver quality and unprecedented performance benefits in our customers' applications including drug and vaccine manufacture, device coating, IVF media, specialized cell culture and cell therapy applications. Benefits: Animal-free Secure supply in large volume quantities cGMP for regulatory-complianceā¦
The cornerstone of all vaccine development efforts at Immunovaccine is the companyās DepoVaxā¢ vaccine adjuvanting platform. DepoVax is a patented vaccine delivery formulation that provides controlled and prolonged exposure of antigens plus adjuvant to the immune system. The result is a strong, specific and sustained immune response with the capability for single-dose effectiveness.The DepoVax platform possesses impressive fleā¦
With Infinite-Technologyā¢ the Lyovaporā¢ L-300 is the first continuous sublimation system available on the market. The instrument contains two alternating condensers that operate at -105 Ā°C and undergo automatic hygenic cleansing. In addition, Infinite-Controlā¢ allows entire process control of all relevant parameters via mobile devices or a stationary computer.
The ALH for FlowCamā¢ Automated Liquid Handling system integrates with FlowCam 8000 series instruments, FlowCam LO, and FlowCam Cyano to automate sample handling and FlowCam operation. ALH for FlowCam minimizes the risk of human error and improves measurement repeatability, ensures safer lab operation, and increases productivity.
Twin-screw extruders are well-established and used in a wide variety of food, polymer, and pharmaceutical applications to efficiently develop and produce high-quality products using a continuous process. Ā The modularity of the Thermo Scientificā¢ Process 11 Twin-screw extrusion equipment provides great flexibility in designing a process to accomplish your food process development goals.
Innovative particle characterization with FlowCamĀ® LO combines flow imaging microscopy (FIM) and light obscuration (LO) into a single analytical solution. Beyond the compendial light obscuration method to fulfill USP <787> and <788> requirements, flow imaging microscopy provides an orthogonal method for quality control of subvisible particulate matter.
AuraĀ® is the particle and aggregate detection system that combines Backgrounded Membrane Imaging which images 100% of your sample to give you count, size, and morphological information, with up to 2 channels of Fluorescence Membrane Microscopy. Identify if particles are protein or not with the first FMM channel and determine if your sample contains lipids, hydrophobic entities, or other aggregates of your choice with a secondā¦
NanoXact Mesoporous Silica Nanospheres - 100 nm, 5 mg/mL in ethanol
NanoXact Mesoporous Silica Nanospheres - (Dried) - 100 nm
AuraĀ® GT helps you realize the promise of gene therapies, without using a lot of your viral vector sample throughout the development process. Avoid conditions and formulations that facilitate viral vector aggregates, monitor DNA leakage, and ensure product quality with just 5 ĀµL of sample per data point.
AuraĀ® PTx gets you to your best formulation faster! Backgrounded Imaging (BMI) technology to give you accurate count, size, and morphology information about particles in your sample. Couple that with Fluorescence Membrane Microscopy (FMM), which gives you definitive ID of protein aggregates and an easy way to monitor polysorbate degradation.
Rapidly develop pharmaceutical formulations and adopt continuous processing methods using the Pharma 16 Twin-Screw Extruder. It can switch between continuous hot melt extrusion (HME) or wet granulation (TSG) with ease. Optimize drug process development parameters with less time and effort than batch processes and easily scale-up to larger Thermo Scientific extruders using minimal amounts of expensive APIs and excipients.Ā
VisualAIā¢, an add-on module for VisualSpreadsheet 6, is a pre-trained, AI-driven image analysis module that recognizes images of biopharmaceutical aggregates captured on any FlowCam 8100 or FlowCam LO instrument. VisualAI is a powerful tool for quantifying protein aggregate and silicone oil droplet content in protein-based drug products.
