Galectins have been implicated in inflammation and cancer, and are useful targets for development of new anti-inflammatory and anticancer therapies. LGALS1 (GAL1) may act as an autocrine negative growth factor that regulates cell proliferation. Lgals1 (gal1) Knockout Rat Characteristics: Homozygous knockout rats display loss of LGALS1 protein via Western blot Background Strain: Sprague-Dawley Research Applications:…
This model contains a bi-allelic deletion within the peroxisome proliferator-activated receptor alpha gene (Ppara). Ppara Knockout Rat Characteristics: Homozygous Knockouts exhibit complete loss of protein via Western blot Background Strain: Sprague-Dawley Research Applications: Lipid metabolism Diabetes Obesity Cell proliferation Wound healing Inflammation/Autoimmune disorders
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Pink1 (PTEN-induced putative kinase 1) gene, encoding for a serine/threonine protein kinase. Mutations in Pink1 are implicated in early-onset Parkinson’s disease. Pink1 knockout rats show both motor impairments and dopaminergic cell loss, making this a useful model of Parkinson’s disease.Pink1 (Park6) Knockout Rat Characterist…
This model contains a biallelic deletion within the Disc1 (disrupted in schizophrenia 1) gene, encoding the DISC1 protein. A translocation disrupting Disc1 was discovered to co-segregate with major psychiatric illness in a Scottish family. This model is useful in the study of schizophrenia.Disc1 Knockout Rat Characteristics: Disc1 is involved in neuronal growth and cortical development The protein also regulates the pro…
This model contains a biallelic deletion of the neuroligin 3 gene (Nlgn3). Mutations in Nlgn3 have been linked with autism and Asperger’s syndrome. This model is useful for understanding the role of neuroligins in the development of autism spectrum disorders.Neuroligin 3 (Nlgn3) Knockout Rat Characteristics: This model was created in collaboration with Autism Speaks and is currently undergoing phenotypic characterization…
Colony Expansion and Custom Breeding Services SAGE® Labs offers continued support for your custom model generation needs. Whether it’s breeding a small cohort of homozygous knockouts for characterization or expansion for regular cohort delivery, our expert staff will work with you to determine the best breeding plan to meet your research goals.Features: Specific pathogen-free facility Comprehensive health monitoring pro…
Developed from a line of Crl:CD(SD) rats. Two lines were developed from this outbred colony, the OP-CD (Obese Prone) and OR-CD (Obese Resistant). This model becomes obese when fed high-fat diets. Obesity develops despite having a fully functioning leptin receptor. The control for this model is the Crl:OR(CD). Model Properties: Coat Color: White (albino) Ideal For: obesity, metabolic syndrome Strain Code: 463
PCSK9 mice were created utilizing a full-length human PSK9 cDNA with a C-terminal V5 tag expressed under the transcriptional control of a composite human albumin promoter containing a 235 bp SV40 enhancer and a 213 bp albumin promoter element. A chimeric intron was inserted between the promoter and PCSK 9 cDNA to enhance expression. The expression cassette was flanked by a 1.2 kb insulator sequence from the chicken beta-globu…
Okamoto, Kyoto School of Medicine, 1963, from outbred Wistar Kyoto male with marked elevation of blood pressure mated to female with slightly elevated blood pressure. Brother x sister mating with continued selection for spontaneous hypertension was then started. To NIH in 1966 from Okamoto at F13. To Charles River from NIH in 1973 at F32.Model Properties: Coat Color: White (albino) MHC Haplotype: RT1k Ideal For: genet…
As study protocols become more complex, so too does the need to have an in vivo model that specifically fits your study design. Charles River offers customized animal preconditioning that is tailored to your research requirements. Whether you need an animal that has been surgically altered, fed a specialized diet or reared to a specific age, we can deliver study-ready animals right to your door, when and where you need them.C…
Developed by Dr. Lewis from Wistar stock in the early 1950s. To Charles River from Tulane in 1970 at F34. Model Properties: Coat Color: White (albino) MHC Haplotype: RT1Â Ideal For: transplantation research, induced arthritis/inflammation, experimental allergic encephalitis, STZ-induced diabetes Strain Code: 004
The Spontaneously Hypertensive Stroke Prone Rat (SHRSP)was isolated from Wistar-Kyoto rats by Okamoto and Aoki in 1963. The A3 subline was transferred to the National Institutes of Health in 1975 from Yamori at generation F36. To Charles River in 2002. Model Properties: Coat Color: White (albino) Ideal For: stroke, ADHD model, nephropathy, hypertension, osteoporosis Strain Code: 324
The PhysioTel F20-EET and F40-EET transmitters are designed primarily for sleep research applications in rodents. These transmitters will allow simultaneous monitoring of two biopotential channels, such as EEG and EMG, temperature, and locomotor activity. The biopotential electrode has an outer diameter of .3mm making the lead an ideal size for use in EEG applications in small animals.Â
FinePointe Resistance and Compliance
You can build custom chamber configurations using any of the rat package designs to meet virtually any research requirement. Additional items to consider include an audio generator, infusion pump, scrambled foot aversive stimulation, lickometer, movement detector, and constant current square wave stimulator. Each operant package is a complete single test station including the SmartCtrl™ interface. Note: Packages do not includ…
Take advantage of our large inventories of common inbred strains and the convenience of having your breeding and drug efficacy needs met by the leading experts in mouse modeling.
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D1 (RvD1) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. A 17(R)-epimer (Item No. 1…
BioIVT has 30+ tissue types available by species in a variety of formats to meet your research needs.
Dextran sulfate sodium salt, or DSS, is a synthetic sulfated branched polysaccharide derivative of dextran that has multiple uses in biomedical and clinical research. One important property of DSS is to triggers colitis in mice and rats when administered in drinking water. Â
The QPS preclinical Neuropharmacology group covers various validated transgenic and non-transgenic in vivo and in vitro models for neurodegeneration such as Alzheimer’s Disease, Parkinson’s Disease, for rare diseases including Huntington’s Disease and ALS, for lipid storage disease and dyslipidemia, and for diseases like psychosis, anxiety, schizophrenia, or autism.Â
Radio-telemetry monitoring of blood pressure, heart rate, ECG, temperature, activity
The M-Seriesâ„¢ systems are cryogen/cooling-free, self-shielded, high-performance MRI systems based on permanent magnet technology. The M-Series systems allow preclinical researchers, with or without in-depth knowledge of MR physics, to utilize the gold standard method in soft tissue imaging without the cost, complexity, and technical burden of superconducting MRI systems.Â
The NEWTON FT-900 is a deeply cooled CCD imager dedicated to SWIR (NIR-I, NIR-II), fluorescence and bioluminescence multi-spectral imaging as it allows for in vivo applications in the visible, near and short-wave infrared spectrum (VIS/ NIR/ NIR-II). Smart and ultra sensitive, it provides non-ionizing and non-invasive visualization of biological processes in real-time.
The SuperArgus PET/CT is a high-performance imaging system it can be configured as a combined PET/CT or PET or CT only system, and features state-of-the-art phoswich PET detectors with true depth-of-interaction (tDOI) for resolution uniformity and high sensitivity. The system offers real-time imaging up to 2.5msec frame rate and advanced capabilities like sensorless cardiac gating and conscious/awake imaging.
