4-Octyl Itaconate
STEMCELL Technologies Inc.Activates nuclear factor erythroid 2-related factor 2 (Nrf2) protein
Activates nuclear factor erythroid 2-related factor 2 (Nrf2) protein
Activin/NODAL/TGF-ß pathway inhibitor; Inhibits ALK5, ALK4, and ALK7
Tyrosine kinase inhibitor; Inhibits EGFR, HER2, JAK2, JAK3 and STAT5a/b
Epigenetic modifier; Inhibits SIRT2 histone deacetylase
PI3K/AKT pathway inhibitor; Inhibits AKT1, AKT2, AKT3
PI3K/AKT pathway inhibitor; Inhibits AKT
Retinoid pathway activator; Activates retinioc acid receptor (RAR) alpha
Epigenetic modifier; Inhibits histone acetyltransferase (HAT)
MEK/ERK pathway inhibitor; Inhibits B-RAF, B-RAFV600E and C-RAF-1
MEK/ERK pathway inhibitor; Inhibits MEK1 and MEK2
Inhibits autophagy and vacuolar H+-ATPase (V-ATPase)
Epigenetic modifier; Inhibits G9a histone methyltransferase
Epigenetic modifier; Inhibits histone deacetylase (HDAC) 6
Src family kinases inhibitor; Inhibits Src, LCK, Yes, Cdc2, EGFR, VEGFR, v-Abl, and FAK
Epigenetic modifier; Inhibits histone methyltransferases SU(VAR)3-9
Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein
Activin/NODAL/TGF-ß pathway inhibitor; Inhibits CK1, ALK5 and p38 MAPK