Vena8 Endothelial+ Biochip: microfluidic flow chamber
The Vena8 Endothelial+™ biochip is ideal for studying cell-cell interaction. Endothelial cells are easily seeded (via standard pipette) and cultured inside the microcapillaries of the biochip. As cells flow through the microcapillary of the Vena8 Endothelial+™ biochip, the cell surface receptors may interact with the endothelial cell monolayer which coats the microcapillary walls. Ideal for use with phase contrast imaging an…
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The Vena8 Endothelial+™ biochip is ideal for studying cell-cell interaction.
Endothelial cells are easily seeded (via standard pipette) and cultured inside the microcapillaries of the biochip. As cells flow through the microcapillary of the Vena8 Endothelial+™ biochip, the cell surface receptors may interact with the endothelial cell monolayer which coats the microcapillary walls. Ideal for use with phase contrast imaging and fluorescence imaging to study cell-cell interactions under conditions mimicking physiological flow.
Oncology: Melanoma – Metastasis
Melanoma is the most aggressive form of skin cancer, which invades deeper layers of the skin and has a propensity to metastasize early. In an effort to provide insight into the mechanism by which melanoma cells metastasize, this application note examines differential cell adhesion within an isogenic model of melanoma progression under physiological shear flow conditions using the Cellix VenaFlux™ Platform.
Inflammation: Leukocyte Adhesion - Quantifying Adhesion, Inhibition, Stimulation
This application note analyses the role of different adhesion molecules and chemokines involved in various stages of inflammation under physiological flow conditions using Cellix’s VenaFluxTM microfluidic platform.
Cardiovascular: Atherosclerosis - Monocyte Adhesion - Chemokines -Oxidized LDL
This application note investigates the role of different stimuli recognized to play an important part in atherosclerosis development (chemokines, cytokines, oxidized lipoproteins) on leukocyte adhesion to endothelial cells or purified adhesion molecules, under physiological flow conditions using Cellix’s VenaFlux™ platform and biochips.
Respiratory: Eosinophil – Inflammation – Adhesion Assay
Cellix Ltd. has developed a novel Microfluidic Platform consisting of a PC-controlled Nanopump with microfluidic biochips and DucoCell analysis software. This application note describes the development of a microfluidic assay to assess the effect of levocetirizine on human eosinophil adhesion using the Cellix Microfluidic Platform.
Dose Response of Effect of Levocetirizine on Eosinophil Adhesion
In this application note the effect of levocetirizine on human eosinophil adhesion to VCAM-1 and BSA is assessed. Using Cellix’s biochips and Mirus pumping system, eosinophil adhesion to rhVCAM-1 and the dose response effect of levocetirizine on GM-CSF-stimulated eosinophil adhesion to rhVCAM-1 under physiological flow conditions is investigated.
T-Cell Adhesion to ICAM-1
This application note investigates the adhesion of T-cells to ICAM-1 when treated with a range of statins (pravastatin, fluvastatin, mevastatin, lovastatin and simvastatin) under physiological flow. The method presented uses Cellix’s biochips and Mirus pumping system.
Preventing Thrombus Formation/Platelet Adhesion to Fibrinogen Using VenaFlux Platform
This application note investigates a range of novel thermoresponsive polymers designed to be used in dual drug-eluting systems in coating stents. Using Cellix’s biochips and Mirus pumping system, platelet adhesion to fibrinogen treated with xemilofiban and fluvastatin eluted from thermoresponvice copolymers and how this effected thrombus formation is investigated.
