Target Deconvolution with CETSA
Target Deconvolution service based on proteome-wide Cellular Thermal Shift Assay using Mass Spectrometry detection is performed in intact cells and lysate without any compound modifications.
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Target deconvolution is a crucial step in drug discovery, as it reveals drug candidate’s interactions with intended and unintended targets. However, traditional methods for target identification are often time-consuming, labor-intensive, and prone to false positives. To overcome these challenges, we offer a service based on the cellular thermal shift assay (CETSA), that measures the thermal stability of proteins in response to compound binding completely label free.
Our service combines the advantages of CETSA with the power of mass spectrometry (MS) to provide comprehensive and reliable target deconvolution results. By subjecting your compound of interest to our target deconvolution service, we can help you identify both direct and indirect protein targets. Our service can be performed on various biological samples, including intact cells, cell lysates, and tissues.
With our CETSA-based target deconvolution service, you can benefit from:
- Fast and robust target deconvolution not requiring modification of your compound and target proteins.
- A comprehensive and unbiased proteome-wide analysis covering over 7,000 proteins and for identification of both on-target and off-target interactions.
- Target Identification in biologically relevant cell system
- Our target deconvolution service can be applied to various aspects of drug discovery research, such as:
- Target identification as follow-up from a phenotypic screen
- Mechanism of action studies
Enhancing research on bifunctional degraders
CETSA® (Cellular Thermal Shift Assay) is a method used in the study of interactions between small molecules and their protein targets. It is particularly useful in targeted protein degradation (TPD), providing valuable insights into degradation profiles. TPD represents a transformative approach in drug discovery yet is still only at the foundations of exploration. Discover how CETSA can elevate advances in monitoring molecular events to elucidate molecular dynamics and cellular effects to benefit pharmaceutical solutions.
Navigating drug discovery in complex environments with Pelago Bioscience
Understanding biological processes is crucial in complex environments, therefore having wider knowledge of the physiological environment improves success in drug discovery, which is often uncertain. Explore CETSA® from Pelago Bioscience, the sophisticated technology used to assess cellular protein-ligand binding. Unlike other target engagement methods, CETSA allows assessment and quantification in cellular environments under actual physiological conditions – without the need to modify the compound or protein.
