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Enhancing research on bifunctional degraders

Pelago Bioscience
25 Nov 2024

CETSA® (Cellular Thermal Shift Assay) is a method used in the study of interactions between small molecules and their protein targets. It is particularly useful in targeted protein degradation (TPD), providing valuable insights into degradation profiles. TPD represents a transformative approach in drug discovery yet is still only at the foundations of exploration. Discover how CETSA can elevate advances in monitoring molecular events to elucidate molecular dynamics and cellular effects to benefit pharmaceutical solutions.

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Target Deconvolution with CETSA

Pelago Bioscience

Target Deconvolution service based on proteome-wide Cellular Thermal Shift Assay using Mass Spectrometry detection is performed in intact cells and lysate without any compound modifications.

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Primary Screening with CETSA

Pelago Bioscience

Primary screening based on Cellular Thermal Shift Assay (CETSA) allows for rapid identification of high quality chemical starting points against the native, full-length protein in live cells. 

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Hit confirmation with CETSA

Pelago Bioscience

Hit confirmation service is based on the Cellular Thermal Shift Assay (CETSA) and  allows for assessment of compound binding to a selected target protein in its native state without any modifications to the protein or the compound. 

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ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Protein ExpressionProtein expression is the utilization of cell machinery for the synthesis of proteins and has become a critical tool in biotherapeutic, genomic, and proteomic research. Produce recombinant proteins with expression vectors in combination with a host cell suitable for high-level protein expression. For production of toxic proteins, consider cell-free expression vectors. Create and monitor post-translational modifications with protein modification kits. Find the best protein expression products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.Protein InteractionsProtein interactions are essential for understanding cellular processes, as proteins work together to carry out biological functions. Studying protein interactions can provide insights into disease mechanisms, drug development, and cell signaling pathways. Explore the best tools for protein interaction research in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Ligands

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Enhancing research on bifunctional degraders