Multidrop™ Combi Reagent Dispenser
Meet your lab's specific needs with outstanding flexibility and performance with the easy-to-use Thermo Scientific™ Multidrop™ Combi Reagent Dispenser.

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Great
Assay biology
Multidrop Combi is really good for liquid dispenser of any type of reagent 1. Example Used for Cell culture Media dispense, DMSO , Buffer. 2. We used for dispensing the Enzyme /substrate/ detection reagent/ media into the 96 well plate, 384 well plate. Very much accurate at 1ul to 300ul Volume
Review Date: 25 Oct 2023 | Thermo Fisher Scientific
Good result, reduce time of assay.
Biochemistry
The Multidrop is pretty user friendly. However, the dispensing needles need to be cleaned very often to remove residual salt and buffer, which is time consuming.
Review Date: 12 Oct 2021 | Thermo Fisher Scientific
Definintely a great addition to Echo liquid handler.
Screening
Multidrop was great for quick dispensing of reagents and topping up buffers in 96well cell culture plates.
Review Date: 27 Jul 2021 | Thermo Fisher Scientific
A workhorse for simple tasks.
Reagent dispensing
These reagent dispensers can be useful for simple dispense patterns across several plate types (96/384). There are sometimes alignment issues and clogging issues (1534 plates especially) so testing is needed before implementing high-throughput.
Review Date: 28 Jan 2020 | Thermo Fisher Scientific
Meet your lab's specific needs with outstanding flexibility and performance with the easy-to-use Thermo Scientific™ Multidrop™ Combi Reagent Dispenser.
The Multidrop Combi system dispenses into a wide selection of plates and volume ranges, providing fast, precise and consistent dispensing and high-throughput operation. Key applications include reproducible dispensing of viable cell suspensions (combine it with the compound dispensing ability of the Thermo Scientific™ Multidrop™ Pico™ Digital Dispenser to enable drug synergy/screening). The Multidrop Combi dispenser also helps optimise SARS-CoV-2 research by rapidly dispensing Thermo Scientific™ KingFisher™ Wash and Elution Buffers.
- Provides precise dispensing over a 0.5 to 2500μL range, ensuring reproducible assay data
- Accommodates microplates from 6 to 1536 wells and plate heights of 5 to 50mm
- Reproducible dispenses viable cells in suspension
- Rapidly fills KingFisher Wash and Elution Plates
- Visual icon-based graphic display makes it easy to use and program, even without training
- Minimal dead volume and back-flushing reduces reagent costs
- Easy to use Thermo Scientific™ FILLit™ Software provides increased flexibility and functionality
- Full robotic compatibility gives increased throughput
Thermo Scientific™ ALPS5000™ Automated Plate Heat Sealer by Thermo Fisher Scientific
Thermo Scientific™ Multidrop™ Pico™ 1 and Pico™ 8 Digital Dispenser by Thermo Fisher Scientific
Enabling drug synergy and drug dose response assays
Developing assays to assess the effectiveness of drug combinations or different doses of single drugs in vitro is an increasingly important area of drug and anticancer therapy research. In developing high throughput assays, researchers face the double challenge of quickly dispensing both viable cells and drug combinations. In particular, the dispensing of two or more compounds to create a dose-response matrix can be both labour intensive and compound expensive.
Next-gen liquid dispensing from microliters to picoliters
Aaron Kettle, Senior Product Manager at Thermo Fisher Scientific, presents two automated liquid handling systems: the Multidrop™ Combi+ Reagent Dispenser and the Multidrop™ Pico™ 8 Digital Dispenser.
The Multidrop™ Combi+ delivers fast, microliter-level dispensing for reagents and cell lines into well plates, ensuring high-speed, efficient workflows. Meanwhile, the Multidrop™ Pico™ 8 is designed for ultra-precise, low-volume liquid handling, making it ideal for applications requiring accuracy at the picoliter scale.
Both systems are tailored for the pharmaceutical and biotech industries, offering reliable performance, intuitive software, and seamless automation to enhance efficiency and reproducibility in the lab.
This video was filmed at SLAS2025.
Accelerate SARS-CoV-2 research detection using the Thermo Scientific Multidrop Combi Reagent Dispenser
In this video, Thermo Fisher Scientific demonstrates how the Thermo Scientific™ Multidrop™ Combi Reagent Dispenser fills Thermo Scientific™ KingFisher™ Wash and Elution Plates in seconds, speeding up SARS-CoV-2 RNA isolation.






















