Products & ReviewSeparations

microOptilab™ Refractive Index Detector for UHPLC

Name: microOptilab™ Refractive Index Detector for UHPLC
SKU: WUTREX
Rating: 4 (1 reviews)

WatersWUTREXAvailable: Worldwide

Universal detection for UHPLC and µSEC-MALS.

4.0/5.0

|1 Review|Write your own Review

$microOptilab™ Refractive Index Detector for UHPLC - Waters | Wyatt Technology - Separations$

$microOptilab™ Refractive Index Detector for UHPLC - Waters | Wyatt Technology - Separations$

The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.

Reviews

Average Rating 4.0

|1Scientists have reviewed this product

Ease of Use

After Sales Service

Value for Money

Write your own review

Ease of use

Average Rating 4.0

Application Area:

Sample Analysis

Great detector

Review Date: 13 May 2024 | Waters

The microOptilab™ differential refractive index (dRI) detector is specifically designed for use with any UHPLC system. It works alone as a universal concentration detector, or in combination with the µDAWN™multi-angle light scattering (MALS) detector to measure absolute molar mass and size of macromolecules and nanoparticles in solution, via µSEC-MALS.

Considering the extremely small peak volumes of UHPLC, band broadening in the microOptilab™ is kept to the absolute minimum, at less than 4 µL, as compared to 20-40 µL or more from other dRI detectors.

Features:

dRI noise: 1.5x10^-9 RIU
dRI range: ±4.7x10^-3 RIU
Dynamic range: 6,000,000:1
Absolute RI sensitivity: ±0.002 RIU
Absolute RI range: 1.2 – 1.8 RIU
Temperature control: heated/cooled 4 - 65°C, including active stabilization—even at room temperature
Wavelength: 660 nm, matched to the µDAWN™; other wavelengths available
Touch-panel display for immediate access to data, diagnostics and settings

Applications:

Universal online concentration measurement for chromatography, especially µSEC-MALS for absolute molecular weight
Analysis of conjugated proteins, co-polymers and nanoparticle-encapsulated drugs/proteins/DNA/RNA when combined with a MALS and UV detector

Application NoteSeparations

Characterization of hyaluronic acid with online multi-angle light scattering and differential viscometry

The biopolymer hyaluronic acid is present in all mammalian systems and is of enormous commercial interest for opthalmic, medical, pharmacological and cosmetic applications. In this application note, the absolute determination of hyaluronic acids' properties is demonstrated using MALS, differential refractometry, and differential viscometry detectors in series with SEC separation.

3 Feb 2025

Product Overview

microOptilab™ Refractive Index Detector for UHPLC

Waters

4.0/5.0

|1 Review

Links

Waters Manufacturer Website

Featured products

Request Quote for All Products

Glycobiology Reagents
Vector Laboratories Inc.
Founded on a growing portfolio of purified lectins, lectin conjugates, and lectin screening kits, Vector Laboratories supports the ability to profile, characterize, and capture complex glycans in biological systems.
(0)
CIMmultus OH
BIA Separations
A tool for chromatographic purification of LNPs as an alternative to filtration methods.
(0)
PATfix LNP Switcher Platform
BIA Separations
Innovative solution that enables investigation of multiple critical attributes for LNP drug products, without extensive sample preparation or dye requirements.
(0)
Bond Elut PFAS WAX/Carbon S SPE Cartridges
Agilent Technologies
Bond Elut dual-phase SPE (Solid Phase Extraction) cartridges feature two of Agilent’s innovative sorbents – the award-winning polymeric weak anion exchange (WAX) and proprietary advanced hybrid carbon material, Carbon S – to provide excellent extraction performance and flow rates for a broad range of per- and polyfluoroalkyl substances (PFAS) compounds.
(0)
Bond Elut Carbon S for PFAS SPE Cartridges
Agilent Technologies
Bond Elut Carbon S for PFAS Cartridges are specifically designed for efficient passthrough matrix cleanup for analysis of per- and polyfluoroalkyl substances (PFAS) in various environmental samples. The advanced Agilent Carbon S sorbent offers an improved balance between analyte recovery and matrix removal efficiency than traditional graphitized carbon black (GCB) sorbent.
(0)
Ascent
Everest Biolabs
Automated extracellular vesicle isolation instrument Isolate extracellular vesicles effortlessly with size exclusion chromatography, enhancing productivity while minimizing operator errors. With the capacity to run multiple SEC columns simultaneously, it uniquely enables high-throughput exosome isolation, finally making large-scale clinical biomarker studies feasible.
(0)
Millipore® Sterivex™ Pressure Filters
Merck
Sterivex-GP Pressure Sterile Filter Unit.
(0)
Agilent 1290 Infinity III Diode Array Detector
Agilent Technologies
The 1290 Infinity III Diode Array Detector (DAD) delivers multiple wavelength detection with full spectra at sampling rates up to 240 Hz for ultrafast UHPLC separations. The Max-Light cartridge cell features optofluidic waveguides, which improve light transmission to near 100% efficiency without sacrificing resolution caused by cell dispersions effects.
(0)
Agilent 1260 Infinity III Binary Pump
Agilent Technologies
The 1260 Infinity III Binary Pump uses high-pressure mixing for UHPLC gradient formation and solvent blending from one or two solvents at pressures up to 600 bar and flow rates up to 5 mL/min.
(0)
Agilent 1260 Infinity III SFC/UHPLC Hybrid System
Agilent Technologies
The 1260 Infinity III SFC/UHPLC Hybrid System allows you to perform supercritical fluid chromatography (SFC) and ultrahigh-performance liquid chromatography (UHPLC) on a single instrument. The system supports pressures up to 600 bar in SFC mode and up to 800 bar in UHPLC mode. Switching between the two modes is easy and can be fully automated.
(0)
Agilent 1260 Infinity III SFC System
Agilent Technologies
The 1260 Infinity III SFC System is a supercritical fluid chromatography (SFC) solution that supports pressures up to 600 bar at flow rates up to 5 mL/min. Its innovative Feed Injection technology enables reproducible injections over a wide range (0.1 to 90 µL).
(0)
Agilent 1290 Infinity III Refractive Index Detector
Agilent Technologies
The 1290 Infinity III Refractive Index Detector (RID) is a UHPLC RID detector that provides excellent sensitivity, resolution, and sample throughput for UHPLC DRI experiments. The 1290 Infinity III RID is a equipped with an ultralow dispersion microflow cell and a data rate of 148 Hz, which significantly reduces run times for higher sample throughput and improved resolution and sensitivity.
(0)
Agilent 1290 Infinity III Bio LC System
Agilent Technologies
The 1290 Infinity III Bio LC System is a UHPLC, binary or quaternary, consisting of biocompatible material for use in biopharma (e.g., critical quality attributes, such as Bio SEC) and other applications utilizing high salt and extreme pH conditions. Biocompatibility ensures the integrity of your biomolecules and robustness of the system.
(0)
Agilent 1290 Infinity III LC System
Agilent Technologies
The Agilent 1290 Infinity III LC is an ultrahigh-performance liquid chromatography (UHPLC) system designed for high efficiency, both in the analytical LC instrument and the lab. It provides a wide power range up to 1300 bar and 5 mL/min for flexible use of columns in UHPLC and HPLC applications. It offers high robustness, as well as unmatched separation and detection performance, ensuring data is of the highest quality.
(0)
Agilent 1260 Infinity III Prime LC System
Agilent Technologies
The 1260 Infinity III Prime LC System is an analytical ultrahigh-performance liquid chromatography instrument. It operates at high pressures and can handle flow rates up to 5 mL/min for using UHPLC columns packed with sub-2 μm particles. This HPLC/UHPLC system gives you the utmost confidence in your HPLC results and is a perfect front end for your LC/MS system.
(1)