Hyperion XTi Imaging System
Unlocking new views in spatial biology. Discover new groundbreaking capabilities for multiplexed tissue imaging at never-before-seen speeds and automation.
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The Hyperion™ XTi Imaging System is now available with three imaging modes for rapid and detailed analysis and automated slide loading for walk-away automation.
Powered by proven Imaging Mass Cytometry™ (IMC™) technology, the Hyperion XTi Imaging System is a multiplexed tissue imager that uses metal-tagged antibodies, instead of fluorophores, to simultaneously and reliably acquire 40-plus protein and RNA markers, without autofluorescence interference. IMC technology is the trusted choice for researchers and continues to be featured in high-impact publications, making it the most reliable tool for highly multiplexed imaging.
See data quickly
Researchers can visualize 40-plus markers in real time, without managing time-consuming acquisition cycles, expediting the time to deeper analysis.
See data clearly
Clearly define areas in any tissue type ― including lung, bone marrow, colon and brain ― without background autofluorescence and spectral overlap.
Load up to 40 slides and walk away
Incorporate a new level of throughput and efficiency with the Hyperion XTi Slide Loader. The optional slide loader enables automatic loading and acquisition of up to 40 slides. It is equipped with a barcoded slide reader for easy sample identification, providing researchers with peace of mind when managing precious tissue samples.
Discover the power of Imaging Mass Cytometry technology
- Image any tissue type with no autofluorescence interference
- Detection of protein and RNA on the same tissue
- Automated slide loader for walk-away acquisition
- Three acquisition modes to accommodate any type of research
- Batch staining workflow for high-volume studies
- Multimodal capabilities with imaging and flow cytometry capabilities
For Research Use Only. Not for use in diagnostic procedures.
Integrated platforms for immunotherapy research and biomarker analysis
Immunotherapy has transformed cancer treatment but 60-70% of patients still fail to respond to these treatments. The challenge lies in accurately identifying which patients will benefit from these therapies due to inadequate predictive biomarkers. However, the solution to this extends far beyond simply identifying more biomarkers.
Addressing existing challenges requires integrated platforms that maintain analytical depth while providing the standardization, throughput, and regulatory compliance needed for clinical implementation. Standard Biotools has developed advanced immune profiling technologies that simultaneously capture functional states, rare cell populations, and spatial relationships to help identify predictive biomarkers for immunotherapy response.
Download this SelectScience guide to explore how to:
- Reveal hidden biomarkers via functional immune profiling
- Scale discovery to clinical reality
- Capture spatial context and dynamic range
- Integrate transcriptomics and proteomics
Resource details:
- Document type: SelectScience guide
- Page count: 40
- Read time: 60 mins
- Edition: 1st
Assessing technical and biological reproducibility of Hyperion XTi System for spatial proteomics
This technical note outlines the Hyperion XTi System's sensitivity consistency (performance stability over a 60-plus-day period) and spatial proteomic reproducibility (biological and technical consistency within and across instruments).
How imaging mass cytometry technology uniquely detects low-abundance biomarkers
This technical note outlines why the high dynamic range of IMC technology is critical for protein quantification and enables the assessment of expression level without saturation of signals. It also outlines the significance of detecting low-level marker expression (highlighting PD-1, PD-L1 and CTLA-4); how IMC technology allows for clear analysis of low-abundance markers, and examples of PD-1, PD-L1 and CTLA-4 marker expression analysis using IMC systems.
