FlowCam 8000
Through its exceptional image quality and the widest size range available, FlowCam® 8000 represents state-of-the-art particle imaging technology. Analyze thousands of particles in less than a minute and comprehensively characterize the size, count, morphology, and identity of subvisible and visible particulates in their native solvent.
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Our productivity has significantly increased since using FlowCam
Algae Classification
Using the FlowCam has increased our productivity three-fold in the last few years compared to using our microscope. There have been questions from our operations about the old microscopy cell counts versus those from FlowCam, so any information regarding comparisons could be helpful.
Review Date: 8 Jul 2025 | Yokogawa Fluid Imaging Technologies, Inc
We use FlowCam to classify and quantify algae and it has made operations more efficient.
Algae classification and quantification.
FlowCam has been an incredible resource for our lab. We have been able to quantify and classify algae much faster than when we used a microscope. This quick turn-around time has been beneficial for our treatment facilities, and it has been a great tool for trending data. There was a little bit of a learning curve in the beginning (around 7 years ago), but since then, we've gotten a pretty good grasp on what context settings work best with what we are monitoring for. Because we have had FlowCam for a while, we've worked with multiple Visual Spreadsheets, and each one has been an improvement. We like using Visual Spreadsheet 4 and 5 simultaneously--one to analyze samples, and the other to classify while another sample is running. Overall, I really enjoy using this instrument and am always so eager and interested in learning new things about FlowCam and how we can constantly make operations more efficient.
Review Date: 8 Jul 2025 | Yokogawa Fluid Imaging Technologies, Inc
All around great product. User-friendly/intuitive software (and hardware) that is capable of a plethora of complex tasks
Algae Quantification/Qualification
Very intuitive and easy to use once trained on. The application itself seems to be very effective and innovative for the time, and it still holds up years later. I am relatively new to my current position, and was able to learn the ins and outs of FlowCam relatively quickly. Customer support, from what I've gathered from my coworkers, is also top tier- with quick and hospitable help whenever we need it. One drawback, however, (which I assume is a problem with many other brands/flow cytometers on the market) is clogging in the cell itself. Of course this will happen time to time, however the method of unclogging it is not as efficient as I would have hoped/liked. All around, though, fantastic product and it surpasses all that is expected of it to perform our jobs efficiently.
Review Date: 8 Jul 2025 | Yokogawa Fluid Imaging Technologies, Inc
Changed the way we do research with powerful easy to use technology
Shellfish Larval research
This instrument has changed the way I work and has greatly increased my productivity in shellfish egg, embryo, and larval research. Much more data and images can be used from this instrument and software that can be obtained with manual microscopy. This is a breakthrough product.
Review Date: 8 Jun 2025 | Yokogawa Fluid Imaging Technologies, Inc
It saves my eyeballs!
Marine pelagic HABs and Cyanobacteria
The FlowCam has saved our eyes from counting large studies by light microscopy. I have had success using it for counting monocultures of dinoflagellates and cyanobacteria. I also used it for a study involving spherical microplastics. I wouldn't call myself an expert yet, but analysis by VisualSpreadsheet has been straight-forward to learn and to train for basic particle analysis.
Review Date: 4 Jun 2025 | Yokogawa Fluid Imaging Technologies, Inc
Overall, I love the FlowCam, it has brought so many amazing things to my research program. Software needs updating.
Phytoplankton Ecology
I really love the FlowCam in terms of the easy of use of the instrument. Having been a long time user, the newest version of the FlowCam works well for my applications (and I don't break the flow cell every time I screw it into the holder). I will say the software is still very clunky. I think that FlowCam needs to embrace AI or other machine learning tools to help make the classification/library process easier. Similarly, there needs to be an easier way to get all the images, individually off the FlowCam in order to input into other tools for processing such as R or python. Also, it is a little disheartening to having to pay for software upgrades each time a new version comes out. Most of us have spent a ton of money on this instrument, and then to have to pay additional is hard. Similarly, some of the replacement pieces can be found online MUCH cheaper then purchased through Fluid Imaging. I get it, you have to make some money, but in the academic world we are on such tight budgets (even more these days) that the discrepancy feels a wrong. Overall, I love the FlowCam, it has allowed me to build collaborations in directions I wouldn't have ever imagined. However, the data processing side is hard, and at times it feels like I cannot get the raw data back out of the instrument, and that should never be.
Review Date: 4 Jun 2025 | Yokogawa Fluid Imaging Technologies, Inc
An asset for increasing research efficiency. One small suggestion for VS6 UI
Marine Molecular Microbiology: Algae
The FlowCam 8000 drastically cuts down on the time needed to perform cell counts, and provides an easy way to process data and images after running plates. In our optimization, it has shown to be less variable than traditional microscopy methods. This instrument has been a good investment for the campus and a valuable asset for our research, despite its care being highly specialized at times. The few drawbacks would be some things involving the Visual Spreadsheets 6. It can be painstaking to go through and select a large amount of certain runs by hand for import, export, or deletion. Maybe provide an option that allows the user to hold shift and drag the mouse to select a large amount of runs?
Review Date: 4 Jun 2025 | Yokogawa Fluid Imaging Technologies, Inc
Makes my job 10x easier and enjoyable
Analyze Phytoplankton
I absolutely love working with this instrument, it is a dream. the capabilities are endless, I use it to process daily water samples and it has cut the analysing time in 1/2 if not by more, plus the fact you can store all the old data runs and look back on them whenever you please. It is an expensive instrument but in my eyes it is well worth the money.
Review Date: 13 Jan 2023 | Yokogawa Fluid Imaging Technologies, Inc
The FlowCam® 8000 Series delivers outstanding particle imaging technology with superior image quality and the broadest size range on the market. Analyze thousands of particles in under a minute while accurately measuring size, concentration, morphology, and identity of subvisible and visible particulates in their native environment.
Flow Imaging Microscopy (FIM) integrates the capabilities of digital imaging, flow cytometry, and traditional microscopy into a single streamlined solution. This approach goes beyond standard particle sizing and counting, enabling in-depth analysis of subvisible API aggregates, contaminants in biopharmaceuticals, mammalian cells, microplankton, emulsions, and advanced materials.
Key Benefits
- Generate detailed results in less than 60 seconds using as little as 100 μL of sample.
- Utilize over 40 morphological parameters to sort, filter, and classify particles.
- Leverage built-in machine learning tools for automated particle identification in protein formulations.
- Analyze samples in their original solvents, including high-viscosity solutions and buffers.
- Boost throughput with automated liquid handling for processing up to 384 samples.
- Identify aquatic organisms with precision using fluorescence detection with FlowCam 8400
Specifications
- Particle sizing and imaging range: 2 µm to 1 mm, with magnification options of 20X, 10X, 4X, and 2X.
- Minimum sample volume requirement: 100 µL.
- Adjustable flow rates from 0.05 mL/min to 10 mL/min, based on flow cell configuration.
- High-resolution camera available in color or monochrome.
- Maximum particle concentration: up to 5 million particles/mL at 2.5 µm particle size.
- Fully compatible with ALH for FlowCam(TM) automated liquid handling.
- Fluorescence excitation options (488 nm, 532 nm, 633 nm) with dual-channel fluorescence detection.
Characterizing protein aggregation with orthogonal and complementary analytical techniques
In this white paper, Yokogawa Fluid Imaging Technolgies discusses the use of flow imaging microscopy (FIM) to analyze subvisible particles in biotherapeutic research. FIM instruments can measure particle characteristics like concentration, size, and morphology, but additional techniques are required to fully characterize the particle content of these samples. To address this, several FlowCam® instruments have been developed that modify the basic FIM technique, such as FlowCam Nano and FlowCam LO. This white paper demonstrates how the combination of FlowCam Nano, FlowCam LO, and dynamic light scattering (DLS) can be used to characterize particles in biotherapeutic samples, including those too small for standard FIM measurements.
