Tosoh Bioscience Introduces CaPure-HA, Hydroxyapatite Chromatography Resin for the Purification of Biological Molecules

20 Oct 2014
Sarah Thomas
Associate Editor

Product news

Tosoh Bioscience LLC, a provider of chromatographic solutions for the separation of biomolecules, announced today the introduction of CaPure-HA, a hydroxyapatite chromatography resin developed for the purification of monoclonal and polyclonal antibodies, the separation of antibody isoforms, isozymes, and the purification of antibody fragments. This resin is now available for sale in the Americas from Tosoh Bioscience.

CaPure-HA chromatography media from Tosoh Bioscience meets the growing demand for resins with better selectivity, resolution and capacity to address the marked proliferation in dimer and other higher order aggregates associated with increased upstream feedstock titers. CaPure-HA resin exhibits dynamic binding capacities of greater than 30 g/L at residence times as low as 2 minutes and greater than 50 g/L at residence times of 5 minutes for human IgGs.

According to Chris Manzari, Marketing Manager for process chromatography media at Tosoh Bioscience LLC” We are very pleased to announce that CaPure-HA is available for order today, providing the combination of exceptional separation properties and unequalled selectivity and resolution for multiple classes of biomolecules. The highly selective and robust nature of CaPure-HA gives chromatographers the flexibility to use this resin at any stage in a process from capture to final polishing”.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Labware and Lab SuppliesLabware and lab supplies include various forms of glassware, plasticware, reagents and personal protective equipment (PPE) and are used across all scientific laboratories, enabling daily tasks to be performed. Explore a range of flasks and beakers, petri dishes, carboys and storage bottles. Labware such as condensers, desiccators and burettes are also available for more specific tasks. Find the best labware and lab supplies in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Monoclonal AntibodiesMonoclonal antibodies (mAbs) are lab-made molecules that can bind to specific antigens on cells, making them highly effective in treating cancers, autoimmune diseases, and infections. These targeted therapies are transforming the treatment landscape for many conditions. Browse our peer-reviewed product directory to find monoclonal antibodies for research and clinical applications; compare products, check reviews, and get pricing directly from manufacturers.Antibody Purification
Tosoh Bioscience Introduces CaPure-HA, Hydroxyapatite Chromatography Resin for the Purification of Biological Molecules