Ca++Pure-HA Chromatography Media
Ca++Pure-HA is a hydroxyapatite resin used in the chromatographic separation of biomolecules.
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Ca++Pure-HA is a hydroxyapatite resin used in the chromatographic separation of biomolecules.
Ca++Pure-HA is specifically developed for the purification of monoclonal and polyclonal antibodies, the separation of antibody isoforms, isozymes, the purification of antibody fragments, and the isolation of single-stranded from double-stranded DNA. Ca++Pure-HA resin has been sintered at high temperatures for increased mechanical and chemical stability, allowing it to withstand the rigors of industrial-scale applications.
Ca++Pure-HA has a demonstrated dynamic binding capacity (DBC), at 10% breakthrough, of greater than 20 g/L for lysozyme at residence times as low as one minute and greater than 30 g/L for human IgG at residence times as low as 2 minutes.
Ca++Pure-HA provides exceptional separation properties and unequalled selectivity and resolution for multiple classes of biomolecules. The highly selective and robust nature of Ca++Pure-HA offers the flexibility to use this resin at any stage in a process from capture to final polishing.
Purification of biomolecules with chromatography techniques
Bioprocess chromatography is an effective purification technique and is key for the successful development and commercialization of new drugs, no matter whether biologic, biosimilar, or biobetter. Explore over twenty application notes covering aspects of biopharmaceutical purification such as capturing of antibody constructs, mAb aggregate removal using salt-tolerant IEC or hydroxyapatite, intermediate purification of bi-specific antibodies with a non-affinity platform using MXC and HIC, antibody-drug conjugates (ADC) purification on HIC resin, or separation of oligonucleotides on highly-selective anion exchanger.
