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Thermo Fisher Scientific Orbitrap LC-MS Systems Now Equipped with IonSense ID-CUBE Ion Source

3 Sept 2013
Sarah Thomas
Associate Editor

Product news

Laboratories analyzing food, pharmaceuticals, neutraceuticals, and other complex samples can now purchase Thermo Scientific Q-Exactive and Exactive Plus LC-MS systems equipped from the factory with IonSense ID-CUBE™ ion sources. This configuration is designed to minimize the need for sample preparation to simplify and speed analyses.

Thermo Fisher Scientific has entered into a value added reseller agreement with IonSense, Inc. to permit Thermo Fisher to sell the ID-CUBE ion source with its two Orbitrap-based LC-MS systems, providing a single point of contact for purchasing, installation and service.

“One of our core values is to make the benefits of powerful mass spectrometry more accessible to larger populations of users,” said Mari Prieto Conaway, product manager, ion sources, Thermo Fisher Scientific. “IonSense shares this vision, and these ion sources support it by greatly simplifying analytical workflows.”

“We are very pleased to expand our relationship with Thermo Fisher,” said Brian Musselman, IonSense president and CEO. “We already have numerous customers using our sources with the Thermo Scientific Exactive systems for pesticide detection, forensics identification, and screening for product quality, and we are excited to further accelerate customers’ work with this new combined offering.”

With the ID-CUBE, a drop of sample is placed onto a metal screen of the IonSense OpenSpot™ Sample Card, which is inserted into the ion source. The screen is quickly heated and the sample is ionized using IonSense’s proprietary Direct Analysis in Real Time (DART®) technology. Ions are then detected by the mass spectrometer in seconds. IonSense promotes the technique as being dramatically faster than conventional separation techniques, requiring minimal training, and producing no solvent waste.

The Thermo Scientific Q Exactive LC-MS system combines quadrupole precursor selection with high-resolution, accurate-mass (HRAM) Orbitrap detection designed for high-confidence identification, quantitation and confirmation. The Thermo Scientific Exactive Plus Orbitrap LC-MS is a benchtop instrument designed for high-performance screening, compound identification and quantitation for high-throughput applications such as environmental analysis, food testing, pharmaceutical QA/QC and forensics.

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Thermo Scientific Exactive Plus Orbitrap LC-MS

Thermo Fisher Scientific

The Exactive Plus Orbitrap LC-MS is a benchtop full scan mass spectrometer designed for compound identification and high-throughput, high-performance screening. The Exactive Plus delivers high resolution accurate mass (HRAM) data and fast, reproducible results for qualitative and quantitative analysis. The availability of HRAM and full scan capability gives you all the data, all the time. It allows retrospective data analysis and eliminates MS method development leading to improved and simplified analytical throughput.Exactive Plus is easy-to-use, cost effective to operate and coupled with workflow-driven software, makes an ideal instrument for new users in routine analytical laboratories.Selected benefits of the Exactive Plus are specified below: High Resolving Power (up to 140,000) - Eliminates isobaric interferences to increase confidence for analysis or complex samples Mass accuracy - Better than 1ppm in full scan and AIF scan using fully automated AGC and mass calibration procedures offers confident identification U-HPLC Scan Speed - The 12Hz scanning frequency of Exactive Plus is fully compatible with U-HPLC and ensures exact mass measurement for fast chromatography applications Fast Polarity Switching - A full cycle of 1 positive and 1 negative scan is performed within 1 second at a resolution setting of 35,000 without sacrificing mass accuracy All-Ion-Fragmentation (AIF) - With multiple dissociation techniques; in source collisional induced dissociation (CID) and high energy collisional dissociation (HCD), provides MS and MS/MS data Full MS scan, AIF scan, data dependent AIF, alternating Full MS and AIF scan Intuitive software interface The Exactive Plus Orbitrap LC-MS is ideal for the following applications: Environmental and Food Safety Clinical Research Forensic Toxicology Drug discovery, metabolism and pharmacokinetics (DMPK) Metabolomics Pharmaceutical BioPharma – Intact Protein analysis Laboratories analyzing food, pharmaceuticals, neutraceuticals, and other complex samples can now purchase Exactive Plus LC-MS system equipped from the factory with IonSense ID-CUBE™ ion sources. This configuration is designed to minimize the need for sample preparation to simplify and speed analyses.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Environmental Monitoring and TestingEnvironmental monitoring and testing uses handheld portable analyzers, kits, spectrometers or chromatography systems for air, water, soil, food and other sample testing. Useful features of analyzers such as BOD and COD include portability, easy calibration, automation and sensitivity.  Environmental test kits for pH, water, moisture, etc, should be accurate, sensitive, reliable, fast and easy to use.Quality ControlQuality control is needed in all production processes. Quality control is a monitoring procedure or set of procedures that are put in place to ensure that a manufactured product adheres to a defined set of quality criteria. PesticidesPesticides are used to protect crops from diseases, pests and unwanted plants. They are classed as persistent organic pollutants (POPs) and can be harmful to humans. The Environmental Protection Agency (EPA) currently regulates the use of pesticides in the USA. Quality TestingQuality testing ensures that products meet required specifications and safety standards in various industries, including pharmaceuticals, food, and materials. It is essential for maintaining product quality and consumer safety. Explore quality testing tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Food TestingFood testing refers to a variety experiments including PCR, mass spectrometry, processing, QuEChERS, analyzing and Kjeldahl.Environmental AnalysisEnvironmental analysis describes a variety of tests that determine the effect of chemicals, processes and particulates such as persistent organic pollutants (POPs) have on the environment.Forensic InvestigationForensic investigation is a diverse collection of scientific techniques and methods for the identification and characterization of chemicals relating to crime scene investigations.

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Thermo Fisher Scientific Orbitrap LC-MS Systems Now Equipped with IonSense ID-CUBE Ion Source