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Seven Forensic Toxicology Application Notes that will Improve your Analysis

SelectScience
11 Dec 2014
Lois Manton-O'Byrne, PhD
Executive Editor

Editorial article

Screening for Classical and Novel Drugs in Pooled Urine Using UPLC-Tof-MSE - Waters
This study presents the results of screening using a method based on UPLC /Tof-MSE. Accurate mass measurement allows the prediction of elemental composition, which is particularly beneficial when dealing with situations involving potential emerging drugs and analogs.

SUPELCO® Application Compendium: Forensic Applications - Sigma-Aldrich
This application compendium presents a series of technical articles covering forensic, clinical and bioanalytical applications. Topics include SPME of VOCs in Breath, Analysis of Vitamin D Metabolite Critical Pairs in Serum, Chiral LC-MS of Methamphetamine, and more.

Proven Approaches for Today’s Forensic/Toxicology Challenges - Agilent Technologies
In this interactive compendium, you’ll find current and emerging applications using LC-MS that will help you to maintain best practices, keep your workflow running smoothly, and meet the stringent chain of custody protocols.

Interlaboratory Tests Demonstrate the Robustness and Transferability of the Toxtyper™ Workflow - Bruker
This application note describes a robust and automated research-based screening solution using the Toxtyper™ for the detection and identification of drugs and drugs of abuse in biological specimens.

Drug Analysis in Hair - Bertin Technologies
This application note describes an HPLC MS/MS method that is designed to quickly establish the toxicological profile of a patient. The Precellys®24 is successfully evaluated on hair grinding, which is considered a difficult and challenging sample.

Modern and Efficient SPE Products for Environmental and Basic Drug Applications: SiliaPrep™ CleanENVI and SiliaPrep™ CleanDRUG - Silicycle Inc.
This poster presents applications using the SiliaPrep CleanDRUG for the analysis of Sibutramine, Ropinirole and Amitriptyline in a human plasma matrix using LC-MS/MS technology.

Quantitative LC-MS Screening for Illicit Drugs Using Ultrahigh Resolution Mass Analysis and Accurate Mass Confirmation - Thermo Scientific
The goal of this application note is to evaluate a simple LC-MS method using a bench-top ultrahigh resolution mass spectrometer to quantitatively screen for 46 illicit drugs of abuse in urine, with minimal sample preparation.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Toxicology / Drugs of Abuse TestingToxicology and Drugs of Abuse Testing is the investigation into toxic and illegal substances found at the scene of a crime or from a suspect and / or victim associated with a scene of a crime. Analyzers, immunoassays and drugs of abuse test kits and presumptive test kits are an essential aspect of toxicology investigation.UrineThe analysis of urine is important in medicinal, anti-doping, forensic and life sciences applications. The ability to evaluate what someone has ingested through their urine enables fast detection and diagnosis of certain illnesses. Volatile Organic Compounds (VOCs)Volatile organic compounds (VOCs) are chemicals that have a low boiling point. Some VOCs are harmful to human health, whereas others can be used to determine the shelf-life of foods samples. Drugs of AbuseA drug of abuse is a drug that has been taken for non-medical purposes. Such drugs can have mind-altering effects, with some causing dependence and addiction.Forensic ToxicologyForensic toxicology is used to determine cause of death, drug use and contaminations. Toxicological evaluations are commonly used in analytical chemistry, clinical, life sciences and forensics.

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