Sensitivity for Screening, Flexibility for Assay Development - The New CLARIOstar® Multi-mode Microplate Reader at SLAS2014

6 Jan 2014
Kerry Parker
CEO

Product news

BMG LABTECH is proud to be a returning Diamond Sponsor for SLAS2014 in San Diego, CA where researchers can see the new and innovative CLARIOstar® microplate reader at Booth #921.

With Triple Detection Technology – filters, a spectrometer, and new advanced LVF Monochromators™ - the CLARIOstar has the sensitivity for mid-throughput screening and the flexibility for assay development. Or team it up with BMG LABTECH’s PHERAstar FS for the ultimate assay development and high throughput screening platform.

Greater Light Transmission, Increased Sensitivity - New, Innovative LVF Monochromators™

Besides being one of the most sensitive microplate readers currently available, the CLARIOstar® has a new, exciting technologically advanced monochromators not found in other readers. LVF Monochromators™ not only have adjustable wavelengths, but also adjustable bandwidths up to 100 nm. Currently, all other monochromators have either fixed or limited bandwidths only up to 30 nm. Thus LVF Monochromators™ can be used for the hundreds of different fluorescent protein, FRET, and BRET assays that require wider bandwidths. Never buy filters for these assays again.

Using patented linear variable filters and linear variable dichroic mirrors to separate light into distinct wavelengths, LVF Monochromators™ are unlike conventional monochromators that use prism gratings. With continuously adjustable bandwidths up to 100 nm and significantly increased sensitivity, LVF Monochromators have filter-like sensitivity and flexibility for fluorescence and luminescence assays.

With the CLARIOstar® Anything is Possible – Any Wavelength, Any Bandwidth, Any Assay. Experience the CLARIOstar® at SLAS2014 at Booth #921.

BMG LABTECH Events at SLAS2014

Also at SLAS2014, BMG LABTECH microplate readers will be highlighted at several tutorials and posters, including:
• Tutorial I: Drug Development Using 3D Engineered Heart Tissues: Screening to Disease Modeling with InvivoSciences on Monday January 20 at 12:30 PM in Room: 28D.
• Labcyte Tutorial II: Miniaturization and Automation of AlphaLISA® Assays with the Labcyte Echo® Liquid Handler and BMG PHERAstar FS on Monday January 20 at 12:30 PM in Room: 28C
• Tutorial III: SPARCL – A ‘No-Wash’ Cost-Effective High-Throughput Screening Alternative for Detecting Antibody-Antigen Interactions with Lumigen on Monday January 20 at 2:00 PM in Room: 24C
• Tutorial IV: Simplifying Protein-Protein Interactions, No Filters Needed - BRET and FRET Applications with a New More Sensitive Monochromator on Tuesday January 21 at 12:30 PM in Room: 25C
• Tutorial V: Improve Flexibility In Your HTS Enzyme Screening With the CLARIOstar® Microplate Reader and Transcreener ® Assays with BellBrook Labs on Tuesday January 21 at 2:00 PM in Room: 25A
• Poster 148: Assessing Epigenetic Enzyme Activity using HTRF® Epigenetic Assays from Cisbio with the PHERAstar FS from BMG LABTECH
• Poster 168: Cell Migration Assays from Platypus Technologies (Oris and Oris Pro) are Digitally Imaged Using the PHERAstar FS from BMG LABTECH.
• Poster 174: Cardiac safety screening with individualized human engineered heart tissues
• Poster 9: Universally Screen Kinase Assays that were Miniaturized Using the Echo® Liquid Handler from Labcyte with BMG LABTECH’s PHERAstar® FS
• Poster 11: More Light, Greater Sensitivity - Revolutionary New LVF Monochromators™ Technology in the CLARIOstar® Microplate Reader
• Poster 31: Validating Assays for High Throughput Enzyme Screening using Transcreener ® Assays from BellBrook Labs and the CLARIOstar® from BMG LABTECH
• Poster 37: Real-time beat-to-beat analysis of excitation-contraction coupling in human engineered heart tissues
• Poster 205: G-protein coupled receptor modulator high throughput screening using the PHERAstar FS from BMG LABTECH to detect Cisbio HTRF® assays miniaturized with Echo® liquid handling from Labcyte

URL: www.bmglabtech.com/slas/

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Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Robotic InstrumentsRobotic instruments can be used for high-throughput automation of many lab processes. Such processes use instruments for assays like cell based assays and ELISA, for sample preparation like shakers, centrifuges and incubators, and for analysis such as sequencing and western blot analyzers. Useful features of robotic instruments include speed, reproducibility, barcode readers, software and automation.Robotic WorkstationsRobotic workstations are automated platforms enabling the user to perform high-throughput, multi-application processes, from sample preparation tasks such as PCR set-up, DNA purification and NGS library preparation, to integrated sample prep and analysis workstations. Automation makes processes consistent, fast, precise and fully walk-away. Find the best robotic workstations in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.Fluorescence Based AssayFluorescence based assays are widely used in life science research and high-throughput screening to measure a broad range of cellular activities.Assay DevelopmentThe process of proving an assay to be sensitive with respect to the target is known as assay development. The assay should be able to characterize novel compounds and measure the potency of these compounds against a validated biological target.