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PerkinElmer Announces New Innovations to Strengthen Drug Discovery Product Portfolio

PerkinElmer
6 Apr 2008

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PerkinElmer, Inc., a global leader in Health Sciences and Photonics, today announced the release of eight new AlphaLISA™ immunoassay kits in conjunction with the Society for Biomolecular Sciences' (SBS) 14th Annual Conference and Exhibition. These latest innovations include research reagents and assays for investigating HIV, cancer, central nervous system disorders, cardiovascular disorders, and diabetes*.

AlphaLISA is a line of highly sensitive "No-Wash" immunoassay reagents offering a wide dynamic range and easy automation for analysis of biomarkers and other analytes. The technology allows researchers to replace multi-step, cumbersome ELISAs with a high throughput screening (HTS) platform, significantly reducing the time, labor and materials necessary for processing complex samples.

"At PerkinElmer, we are committed to providing our customers with the technologies and innovations they need to further push the boundaries of research taking place in today's laboratories," said Richard Eglen, Ph.D., president, Bio-discovery, PerkinElmer, Inc. "The release of these eight new AlphaLISA assay kits will not only provide researchers with the latest tools they need to produce more accurate results across a wider range of diseases, but also expand and strengthen our line of drug discovery products in new and existing markets."

AlphaLISA is a proprietary bead-based homogeneous assay technology for the detection of analytes in complex samples such as serum. In addition, the proximity of the two beads allows the detection of very large analytes such as full length endogenous proteins and biological complexes. The beads are extremely small in comparison to other bead technologies and can be dispensed very easily. AlphaLISA's unique, No-Wash technology eliminates tedious ELISA washing and consecutive incubation wait times, and offers greater dynamic range and sensitivity, while enabling miniaturization and ease of automation.

*AlphaLISA assay kits are intended for research use only and are not for use in diagnostic procedures.

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Alpha is a bead-based, no-wash luminescent technology. When Alpha Donor and Acceptor beads are brought together through binding to target, a cascade of chemical reactions is set in motion, creating an amplified signal. These versatile beads are conjugated with various biomolecules that enable detection of unique biological events, offering maximum flexibility.

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ELISAEnzyme-linked immunosorbent assays (ELISA), also known as enzyme immunoassays (EIA), are used for the detection and quantification of proteins, peptides and antibodies in a sample. ELISA often comes in kit format, with pre-selected antibody pairs to detect specific proteins or biomarkers of diseases such as diabetes and obesity, or cardiovascular and neurological disorders. Detection is made possible with chemiluminescent, fluorescent or colorimetric substrates and detection instruments such as microplate / ELISA readers. Other kits available include: Enzyme-linked immunospot (ELISPOT) assays for the quantification of protein-producing cells and chemiluminescent immunoassays (CLIA) kits. Find the best ELISA kits and products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.

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PerkinElmer Announces New Innovations to Strengthen Drug Discovery Product Portfolio